Ontology
title: ACGT Master Ontology
creator: Cristian Cocos
creator: Holger Stenzhorn
publisher: Insitute for Formal Ontology and Medical Information Science (IFOMIS)
creator: Mathias Brochhausen
creator: Sarah Lerch
creator: Ulf Schwarz
imports: bfo-1.1.owl
imports: ro-1.0.owl

catalystFor
type: ObjectProperty
comment: Ideally, the range should be confined to chemical processes
domain: ChemicalSubstance
sub property of: facilitates
inverse of: hasCatalyst
range: ProcessualEntity

contralateralTo
type: ObjectProperty
type: SymmetricProperty
comment: def = "On the other side. The contralateral breast is the breast on the other breast. A stroke affecting the right side of the brain may cause contralateral paralysis, affecting the left arm and leg. The opposite of contralateral is ipsilateral which refers to the same side." Not sure what the domain might be though...
domain: Entity
range: Entity

grafts
type: ObjectProperty
comment: see http://en.wikipedia.org/wiki/Medical_grafting
range: MaterialOrganismalIndependentContinuant
domain: SurgicalProcedure
sub property of: adds
inverse of: graftedBy

ipsilateralTo
type: ObjectProperty
type: SymmetricProperty
comment: def = "On the same side. A study of "ipsilateral breast tumor recurrence following lumpectomy and radiation therapy" pertains to cancer returning in the same breast as has been treated. A lesion in the right side of the brain may affect vision ipsilaterally, in the right eye." Not sure what the domain migh be though...
domain: Entity
range: Entity

locusOf
type: ObjectProperty
comment: There's another RO relation called "locationOf," which is why I have renamed this to locusOf.
domain: Site
range: ProcessualEntity

magnitudeOf
type: ObjectProperty
comment: synonyms: assessment, evaluation
domain: Magnitude
range: Entity

reveals
type: ObjectProperty
comment: The corect way to deal with "reveals" is to make it a 3 place relation: x reveals quality of y. Existence is a property, so we shouldn't feel compelled to add "process" to the range.
domain: DiagnosticProcess
inverse of: revealedBy
range: Class
  union of: Quality
  union of: ProcessualEntity

subsystemOf
type: ObjectProperty
comment: a part is a subsystem in case it has some contribution to the function of the greater system (i.e. is not causally inert)
inverse of: hasSubsystem
range: IndependentContinuant
domain: IndependentContinuant
sub property of: partOf

undergoes
type: ObjectProperty
comment: the key difference b/w participatesIn and undergoes is that the continuant that undergoes a process is the largest continuant that undergoes that process
domain: Continuant
sub property of: participatesIn
range: Class
  union of: StateOfAffairs
  union of: FiatProcessPart
  union of: Process

undergoesMedicalProcess
type: ObjectProperty
comment: old name: undergoesMedicalProcedure
range: MedicalProcess
domain: Organism
sub property of: undergoes

ABVDChemo
type: Class
subclass of: Chemotherapy
disjoint with: ACChemo
disjoint with: BEPChemo
disjoint with: C-VAMPChemo
disjoint with: CAFChemo
disjoint with: CAVChemo
disjoint with: CHOPChemo
disjoint with: CMFChemo
disjoint with: CapecitabineDocetaxelChemo
disjoint with: CarboplatinEtoposideChemo
disjoint with: ChlVPPChemo
disjoint with: CisplatinFluorouracilChemo
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: ABVD is named after the initials of the chemotherapy drugs used, which are: doxorubicin (pronounced docks-o-rou-bi-sin, originally called Adriamycin®) bleomycin (blee o my sin), vinblastine (vin blas teen) and dacarbazine (de car b zeen).

ACChemo
type: Class
subclass of: Chemotherapy
disjoint with: BEPChemo
disjoint with: C-VAMPChemo
disjoint with: CAFChemo
disjoint with: CAVChemo
disjoint with: CHOPChemo
disjoint with: CMFChemo
disjoint with: CapecitabineDocetaxelChemo
disjoint with: CarboplatinEtoposideChemo
disjoint with: ChlVPPChemo
disjoint with: CisplatinFluorouracilChemo
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: AC is named after the initials of the drugs used and involves the chemotherapy drugs doxorubicin (pronounced docks-o-rou-bi-sin, originally known as Adriamycin®) and cyclophosphamide (sigh clo fos fa mide).

AJCDifferentiation
type: Class
subclass of: DifferentiationClass
disjoint with: BloomRichardsonDifferentiation
disjoint with: FuhrmanNuclearGrade
disjoint with: GleasonDifferentiation
comment: recommended by the American Joint Commission on Cancer

ALPLevel
type: Class
subclass of: Density
comment: aka AlkalinePhosphatase Level

ALTCount
type: Class
subclass of: Density
comment: Alanine transaminase (ALT) Count

ANC
type: Class
subclass of: HematologicalBiochemicalTest
subclass of: Restriction
  on property: reveals
  all values from: ANCount
subclass of: Restriction
  on property: reveals
  some values from: ANCount
comment: CountingAbsoluteNeutrophils

ANCount
type: Class
subclass of: Density
comment: Absolute neutrophil count (ANC)

AR
type: Class
subclass of: SexHormone
comment: aka Androgen receptor; the androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone.

ASTCount
type: Class
subclass of: Density
comment: Aspartate transaminase (AST) Count

AT/RT
type: Class
subclass of: RhabdoidTumor
comment: Rhabdoid Tumor in the brain Short for Atypical Teratoid/Rhabdoid Tumor

AbsoluteNeutrophilCount
type: Class
subclass of: Magnitude
comment: Abbr.: ANC

Actinomycin-D
type: Class
subclass of: PharmaceuticalSubstance
disjoint with: Anthracycline
disjoint with: Arimidex
disjoint with: Carboplatin
disjoint with: DigitalisGlycoside
disjoint with: Docetaxel
disjoint with: Etoposide
disjoint with: Furosemide
disjoint with: Herceptin
disjoint with: Lomustine
disjoint with: Mannitol
disjoint with: Spironolactone
disjoint with: Tamoxifen
disjoint with: Taxotere
disjoint with: Thiazide
disjoint with: Vincristine
disjoint with: Zoladex
comment: Synonym: Dactinomycine

AddressPart
type: Class
equivalent class: Class
  union of: CountryName
  union of: HouseNumber
  union of: PlaceName
  union of: PostalCode
  union of: StreetName
subclass of: Identifier
subclass of: Restriction
  on property: partOf
  some values from: Address
subclass of: Restriction
  on property: hasStringValue
  cardinality: 1

AdjuvantTherapy
type: Class
subclass of: SupportingTherapy
disjoint with: NeoadjuvantTherapy
comment: = treatment given after the primary treatment to increase the chances of a cure. Adjuvant therapy may include chemotherapy, radiation therapy or hormone therapy

Adriamycin
type: Class
subclass of: Anthracycline
subclass of: Restriction
  on property: hasSameMainActiveIngrediantAs
  some values from: Doxorubicin
disjoint with: Daunorubicin
disjoint with: Doxorubicin
disjoint with: Epirubicin
disjoint with: Rubex
comment: =Doxorubicin

Age
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1
disjoint with: BinaryStatus
disjoint with: Dose
disjoint with: LVEF
disjoint with: LVSF
disjoint with: NumberOfCycles
disjoint with: PhysicalMagnitude
disjoint with: StressLevel
disjoint with: ToxicityLevel
disjoint with: pCRRate

Allergy
type: Class
subclass of: NonInfectiousDisease
subclass of: Restriction
  on property: hasRole
  on class: GeneralizedSymptom
  min qualified cardinality: 0
disjoint with: Asthenia
disjoint with: Fever
disjoint with: NightSweating

Alopecia
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: IntergumentarySystemSymptom
  min qualified cardinality: 0

AnatomicalStructure
type: Class
subclass of: CanonicalMaterialOrganismalIndependentContinuant
subclass of: Restriction
  on property: locatedIn
  all values from: Organism
subclass of: Restriction
  on property: hasQuality
  some values from: Normality
subclass of: Restriction
  on property: undergoes
  on class: Teletherapy
  min qualified cardinality: 0
subclass of: Restriction
  on property: locatedIn
  some values from: Organism

Anemia
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: HemolymphoidSystemSymptom
  min qualified cardinality: 0
disjoint with: CoagulationDisorder

Anthracycline
type: Class
subclass of: PharmaceuticalSubstance
disjoint with: Arimidex
disjoint with: Carboplatin
disjoint with: DigitalisGlycoside
disjoint with: Docetaxel
disjoint with: Etoposide
disjoint with: Furosemide
disjoint with: Herceptin
disjoint with: Lomustine
disjoint with: Mannitol
disjoint with: Spironolactone
disjoint with: Tamoxifen
disjoint with: Taxotere
disjoint with: Thiazide
disjoint with: Vincristine
disjoint with: Zoladex
comment: Anthracyclines are a class of chemotherapeutic agents based upon daunosamine and tetra-hydro-naphthacene-dione.

AntiTumorAntibiotic
type: Class
subclass of: ChemotherapyDrug
subclass of: Restriction
  on property: isCellCycleSpecific
  has value: true
disjoint with: AromataseInhibitor
disjoint with: SERM

Arrhythmia
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: CardiacSymptom
  min qualified cardinality: 0
disjoint with: CardiacArrest

ArrhythmiaGrade0
type: Class
subclass of: ArrhythmiaGrade
disjoint with: ArrhythmiaGrade1
disjoint with: ArrhythmiaGrade2
disjoint with: ArrhythmiaGrade3
disjoint with: ArrhythmiaGrade4
comment: definition: No toxicity

ArrhythmiaGrade1
type: Class
subclass of: ArrhythmiaGrade
disjoint with: ArrhythmiaGrade2
disjoint with: ArrhythmiaGrade3
disjoint with: ArrhythmiaGrade4
comment: definition: Asymptomatic, no treatment

ArrhythmiaGrade2
type: Class
subclass of: ArrhythmiaGrade
disjoint with: ArrhythmiaGrade3
disjoint with: ArrhythmiaGrade4
comment: definition: symptomatic, no treatment

ArrhythmiaGrade3
type: Class
subclass of: ArrhythmiaGrade
disjoint with: ArrhythmiaGrade4
comment: definition: Requiring treatment

ArrhythmiaGrade4
type: Class
subclass of: ArrhythmiaGrade
comment: definition: Hypotension, life-threatening

Arthralgia
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: MusculoskeletalSystemSymptom
  min qualified cardinality: 0
disjoint with: Myalgia

Asthenia
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: GeneralizedSymptom
  min qualified cardinality: 0
disjoint with: Fever
disjoint with: NightSweating

Ataxia
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: undergoneBy
  on class: Trunk
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoneBy
  on class: FreeLimb
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0

BEPChemo
type: Class
subclass of: Chemotherapy
disjoint with: C-VAMPChemo
disjoint with: CAFChemo
disjoint with: CAVChemo
disjoint with: CHOPChemo
disjoint with: CMFChemo
disjoint with: CapecitabineDocetaxelChemo
disjoint with: CarboplatinEtoposideChemo
disjoint with: ChlVPPChemo
disjoint with: CisplatinFluorouracilChemo
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: BEP is named after the initials of the chemotherapy drugs used, which are: bleomycin (pronounced blee-o-my-sin), etoposide (e-top-o-side) and cisplatin (sis-pla-tin), which contains platinum.

BenignNeoplasm
type: Class
subclass of: Neoplasm
subclass of: Restriction
  on property: hasMetastasis
  cardinality: 0
subclass of: Restriction
  on property: hasMalignancy
  has value: NoMalignancy
disjoint with: MalignNeoplasm
disjoint with: SemiMalignNeoplasm

Betablocker
type: Class
subclass of: Drug
comment: Syn.: Beta Receptor-Blocker

BioBankingOrganization
type: Class
subclass of: Institution
subclass of: Restriction
  on property: stores
  on class: SubstanceSample
  min qualified cardinality: 0

BiologicalIndependentContinuant
type: Class
subclass of: Object
subclass of: Restriction
  on property: receivesPreTherapy
  on class: PreTherapy
  min qualified cardinality: 0
disjoint with: ChemicalSubstance
disjoint with: Institution

BiopsyNeedle
type: Class
subclass of: TechnicalObject
subclass of: Restriction
  on property: hasQuality
  on class: Magnitude
  min qualified cardinality: 0
subclass of: Restriction
  on property: participatesIn
  on class: BiopsyWithoutIncision
  min qualified cardinality: 0

BiopsyWithoutIncision
type: Class
subclass of: Biopsy
subclass of: Restriction
  on property: hasParticipant
  on class: BiopsyNeedle
  min qualified cardinality: 0

BloodPlasmaSample
type: Class
subclass of: SubstanceSample
subclass of: Restriction
  on property: sampledFrom
  some values from: Organism
disjoint with: BloodSample
disjoint with: HistologicalSample
disjoint with: UrineSample
comment: aka serum sample

BloodPressure
type: Class
subclass of: Pressure
subclass of: Restriction
  on property: bloodPressureOf
  on class: HumanBeing
  qualified cardinality: 1

BloodSample
type: Class
subclass of: SubstanceSample
subclass of: Restriction
  on property: contains
  on class: NumberOfBloodCells
  min qualified cardinality: 0
subclass of: Restriction
  on property: sampledFrom
  some values from: Organism
disjoint with: HistologicalSample
disjoint with: UrineSample

BloodSerumSample
type: Class
subclass of: SubstanceSample
subclass of: Restriction
  on property: implements
  on class: CatecholaminLevel
  min qualified cardinality: 0

BloomRichardsonDifferentiation
type: Class
subclass of: DifferentiationClass
disjoint with: FuhrmanNuclearGrade
disjoint with: GleasonDifferentiation
comment: used for breast cancer; Wikipedia: The Bloom-Richardson grade (BR grade) is a a histologic grade assigned by pathologists to breast cancers. It is the most common type of cancer grade system currently used. It is a semi-quantitative grading method based on three morphologic features of invasive breast cancers. The morphologic features that are used are: degree of tumor tubule formation (percentage of cancer composed of tubular structures) tumor mitotic activity (rate of cell division) nuclear pleomorphism of tumor cells (nuclear grade, change in cell size and uniformity) Each of these features is assigned a score ranging from 1 to 3. The scores are then added together for a final sum that will range between 3 to 9. This value is then used to grade the tumor as follows : 3-5 Grade 1 tumor (well-differentiated). 6-7 Grade 2 tumor (moderately-differentiated). 8-9 Grade 3 tumor (poorly-differentiated).

BodyMassIndex
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1

BodySurfaceArea
type: Class
subclass of: SurfaceSize
comment: aka BSA: In physiology and medicine, the body surface area (BSA) is the measured or calculated surface of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Estimation of BSA is simpler than many measures of volume.

Breadth
type: Class
subclass of: Length
disjoint with: Depth
disjoint with: Diameter
disjoint with: Height
disjoint with: Width
comment: ?

C-VAMPChemo
type: Class
subclass of: Chemotherapy
disjoint with: CAFChemo
disjoint with: CAVChemo
disjoint with: CHOPChemo
disjoint with: CMFChemo
disjoint with: CapecitabineDocetaxelChemo
disjoint with: CarboplatinEtoposideChemo
disjoint with: ChlVPPChemo
disjoint with: CisplatinFluorouracilChemo
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: C-VAMP is named after the initials of the chemotherapy drugs used in the treatment, which are cyclophosphamide (pronounced sigh-clo-fos-fa-mide), vincristine (vin-chris-teen), doxorubicin (docks-o-rou-bi-sin, originally called Adriamycin®) and methyl-prednisolone (me-thile pred-ni-so-lone), which is a steroid.

CAFChemo
type: Class
subclass of: Chemotherapy
disjoint with: CAVChemo
disjoint with: CHOPChemo
disjoint with: CMFChemo
disjoint with: CapecitabineDocetaxelChemo
disjoint with: CarboplatinEtoposideChemo
disjoint with: ChlVPPChemo
disjoint with: CisplatinFluorouracilChemo
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: CAF is named after the initials of the drugs involved. These are: cyclophosphamide (pronounced sigh-clo-fos-fa-mide), doxorubicin (docks-o-roo-bi-sin, originally called Adriamycin®) and fluorouracil (floo-ro-you-ro-sill, also known as 5FU).

CAVChemo
type: Class
subclass of: Chemotherapy
disjoint with: CHOPChemo
disjoint with: CMFChemo
disjoint with: CapecitabineDocetaxelChemo
disjoint with: CarboplatinEtoposideChemo
disjoint with: ChlVPPChemo
disjoint with: CisplatinFluorouracilChemo
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: CAV is named after the initials of the chemotherapy drugs used, which are: cyclophosphamide (pronounced sigh-clo-fos-fa-mide), doxorubicin (docks-o-rou-bi-sin), which was originally called Adriamycin® and vincristine (vin-chris-teen).

CD3+
type: Class
subclass of: Magnitude
comment: Def.: The magnitude of the activity level of T cells.

CD34SelectionPurging
type: Class
subclass of: Purging
comment: Def.: A purging process selecting the componenets of a sample by using antigen CD34 as indicator. The result is a sample of only stem cells.

CHOPChemo
type: Class
subclass of: Chemotherapy
disjoint with: CMFChemo
disjoint with: CapecitabineDocetaxelChemo
disjoint with: CarboplatinEtoposideChemo
disjoint with: ChlVPPChemo
disjoint with: CisplatinFluorouracilChemo
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: R-CHOP is named after the chemotherapy drugs used in the treatment. It involves the monoclonal antibody rituximab (pronounced ri-tucks-i-mab), and the drugs: cyclophosphamide (sigh-clo-fos-fa-mide), doxorubicin (docks-o-rou-bi-sin, originally called Adriamycin®), vincristine (vin-chris-teen, originally known as Oncovin®) and prednisolone (pred-ni-so-lone), which is a steroid.

CMFChemo
type: Class
subclass of: Chemotherapy
disjoint with: CapecitabineDocetaxelChemo
disjoint with: CarboplatinEtoposideChemo
disjoint with: ChlVPPChemo
disjoint with: CisplatinFluorouracilChemo
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: CMF is named after the initials of the chemotherapy drugs involved, which are cyclophosphamide (pronounced sigh-clo-fos-fa-mide), methotrexate (me-tho-trex-ate) and fluorouracil (floo-ro-you-ro-sill, which is also known as 5FU).

CRF
type: Class
subclass of: Document
subclass of: Restriction
  on property: undergoes
  on class: FillingInCaseReportForm
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasPart
  some values from: HospitalIdentifier
disjoint with: ConsentForm
disjoint with: PatientLetter
disjoint with: Protocol
disjoint with: Questionnaire

CWSChemotherapyRegime
type: Class
subclass of: ChemotherapyRegime
comment: Chemotherapy regime according to the "Cooperative Weichteilsarkom Studie"

CanonicalMaterialOrganismalIndependentContinuant
type: Class
subclass of: MaterialOrganismalIndependentContinuant
subclass of: Restriction
  on property: hasPartNeoplasm
  on class: Neoplasm
  min qualified cardinality: 0
comment: ALL FMA classes under "FMA: MaterialAnatomicalEntity" are subsumed here.

CapecitabineDocetaxelChemo
type: Class
subclass of: Chemotherapy
disjoint with: CarboplatinEtoposideChemo
disjoint with: ChlVPPChemo
disjoint with: CisplatinFluorouracilChemo
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: The treatment involves the two chemotherapy drugs: capecitabine (pronounced cap-sight-a-been) and docetaxel (doe-se-tax-el), which is commonly called Taxotere® (tax-oh-tare).

CarboplatinEtoposideChemo
type: Class
subclass of: Chemotherapy
disjoint with: ChlVPPChemo
disjoint with: CisplatinFluorouracilChemo
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: The treatment involves two chemotherapy drugs: carboplatin (pronounced car-bo-pla-tin) and etoposide (e-top-o-side), which is also known as Etopophos® or Vepesid®.

CardiacArrest
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: isFunctionalOrStructural
  has value: Functional
subclass of: Restriction
  on property: hasRole
  on class: CardiacSymptom
  min qualified cardinality: 0

CardiacMurmur
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: CardiacSymptom
  min qualified cardinality: 0

CardioPerformanceClassI
type: Class
subclass of: CardioPerformanceRating
disjoint with: CardioPerformanceClassII
disjoint with: CardioPerformanceClassIII
disjoint with: CardioPerformanceClassIV
comment: patients with no limitation of activities; they suffer no symptoms from ordinary activities.

CardioPerformanceClassII
type: Class
subclass of: CardioPerformanceRating
disjoint with: CardioPerformanceClassIII
disjoint with: CardioPerformanceClassIV
comment: patients with slight, mild limitation of activity; they are comfortable with rest or with mild exertion.

CardioPerformanceClassIII
type: Class
subclass of: CardioPerformanceRating
disjoint with: CardioPerformanceClassIV
comment: patients with marked limitation of activity; they are comfortable only at rest.

CardioPerformanceClassIV
type: Class
subclass of: CardioPerformanceRating
comment: patients who should be at complete rest, confined to bed or chair; any physical activity brings on discomfort and symptoms occur at rest.

CatecholaminLevel
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: implementedBy
  on class: UrineSample
  min qualified cardinality: 0
subclass of: Restriction
  on property: implementedBy
  on class: BloodSerumSample
  min qualified cardinality: 0

Catecholamine
type: Class
subclass of: BiogenicAmine
subclass of: Restriction
  on property: hasRole
  on class: TumorMarker
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasRole
  some values from: Hormone
disjoint with: GranulocyteColonyStimulatingFactor
disjoint with: LH-RH

CerebrospinalLiquidPuncture
type: Class
subclass of: DiagnosticProcess
subclass of: Restriction
  on property: creates
  on class: CerebrospinalLiquidSample
  min qualified cardinality: 0

CerebrospinalLiquidSample
type: Class
subclass of: SubstanceSample
subclass of: Restriction
  on property: contains
  on class: TumorCell
  min qualified cardinality: 0
subclass of: Restriction
  on property: createdBy
  on class: CerebrospinalLiquidPuncture
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: TumorCellCounting
  min qualified cardinality: 0

ChemicalSubstance
type: Class
subclass of: Object
subclass of: Restriction
  on property: hasRole
  on class: ContrastMedium
  min qualified cardinality: 0
subclass of: Restriction
  on property: participatesIn
  on class: MagneticResonanceImaging
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasQuality
  on class: ToxicityLevel
  qualified cardinality: 1
subclass of: Restriction
  on property: participatesIn
  on class: Computertomography
  min qualified cardinality: 0
disjoint with: Institution

Chemotherapy
type: Class
subclass of: Pharmacotherapy
subclass of: Restriction
  on property: hasRole
  on class: AdjuvantChemotherapy
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasMagnitude
  some values from: NumberOfCycles
subclass of: Restriction
  on property: hasRole
  some values from: Class
    union of: AdjuvantChemotherapy
    union of: NeoadjuvantChemotherapy
    union of: PrimaryTherapy
subclass of: Restriction
  on property: hasRole
  some values from: Class
    union of: PrimaryTherapy
    union of: SupportingTherapy
subclass of: Restriction
  on property: hasRole
  on class: NeoadjuvantChemotherapy
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasMagnitude
  on class: NumberOfLatenessDays
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasQuality
  on class: Lateness
  min qualified cardinality: 0
disjoint with: GeneTherapy
disjoint with: HormonalTreatment
disjoint with: Immunotherapy
disjoint with: SupportivePharmacotherapy

ChemotherapyDrug
type: Class
subclass of: Drug
subclass of: Restriction
  on property: isCellCycleSpecific
  cardinality: 1
disjoint with: Diuretic
disjoint with: HormoneTherapyDrug
disjoint with: ImmunotherapyDrug

ChlVPPChemo
type: Class
subclass of: Chemotherapy
disjoint with: CisplatinFluorouracilChemo
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: ChlVPP is named after the initials of the chemotherapy drugs used, which are chlorambucil (pronounced claw-ram-bu-cil), vinblastine (vin-blas-teen), procarbazine (pro-car-ba-zeen) and prednisolone (pred-ni-so-lone), which is a steroid.

Chromosome
type: Class
subclass of: CellComponent
subclass of: Restriction
  on property: undergoes
  on class: ChromosomeAberration
  min qualified cardinality: 0

ChromosomeAberration
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: undergoneBy
  on class: Chromosome
  min qualified cardinality: 1
subclass of: Restriction
  on property: hasName
  on class: Name
  min qualified cardinality: 1

CisplatinFluorouracilChemo
type: Class
subclass of: Chemotherapy
disjoint with: DHAPandARDHAPChemo
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: This treatment involves two chemotherapy drugs: cisplatin (pronounced sis-pla-tin) and fluorouracil (floo-ro-you-ro-sill); which is also known as 5FU.

ClinicalClassTNM
type: Class
equivalent class: Class
  union of: MClass
  union of: NClass
  union of: TClass
subclass of: MammaryCarcinomaClass
comment: Clinical classification (Pretreatment clinical classification), designated TNM (or cTNM). This is based on evidence acquired before treatment. Such evidence arises from physical examination, imaging, endoscopy, biopsy, surgical exploration and other relevant examinations.

ClinicalExamination
type: Class
subclass of: DiagnosticProcess
subclass of: Restriction
  on property: undergoneBy
  some values from: Organism
comment: aka Physical Examination

ClinicalResearch
type: Class
subclass of: AdministrativeProcess
subclass of: Restriction
  on property: hasParticipant
  on class: HumanBeing
  min qualified cardinality: 0
subclass of: Restriction
  on property: undertakenBy
  min cardinality: 1
disjoint with: PreClinicalResearch
disjoint with: ProtocolChange
disjoint with: Registration

ClinicalStudy
type: Class
equivalent class: Class
  union of: PrimaryClinicalStudy
  union of: SecondaryClinicalStudy
subclass of: ClinicalResearch
subclass of: Restriction
  on property: describedBy
  on class: InformationObject
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasParticipant
  on class: TherapyPlan
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasName
  some values from: Name
subclass of: Restriction
  on property: hasProtocol
  some values from: ClinicalStudyProtocol
disjoint with: ClinicalTrial

ClinicalStudyIdentifier
type: Class
subclass of: Identifier
disjoint with: ClinicalTrialIdentifier
disjoint with: InstitutionIdentifier
disjoint with: LegalGuardianIdentifier
disjoint with: MedicalExpertIdentifier
disjoint with: PatientIdentifier
disjoint with: RegistryIdentifier
disjoint with: TelephoneNumber
comment: Name or other identifier of a clinical study in which the patient might be enrolled.

ClinicalStudyPatientNumber
type: Class
subclass of: PatientIdentifier
disjoint with: GPOH-PID
disjoint with: IMBEIIdentifier
disjoint with: RegistrationNumber
comment: ???????

Coagulopathy
type: Class
subclass of: HematologicalDisease
comment: aka "coagulation disorder"

Cobalt-60
type: Class
subclass of: ChemicalSubstance
subclass of: Restriction
  on property: participatesIn
  on class: Radiotherapy
  min qualified cardinality: 0
comment: Def.: Cobalt-60 is a chemical substance (a metal) that is radioactive and used in radiotherapy.

ColloidCarcinoma
type: Class
subclass of: InvasiveMammaryCarcinoma
disjoint with: InflammatoryCarcinoma
disjoint with: InvasiveDuctalCarcinoma
disjoint with: InvasiveLobularCarcinoma
disjoint with: MedullaryCarcinoma
disjoint with: TubularCarcinoma
comment: aka MucinousCarcinoma

CommonToxicityCriteriaGrade
type: Class
subclass of: ToxicityLevel
subclass of: Restriction
  on property: isQualityOf
  on class: TherapeuticProcess
  min qualified cardinality: 1
comment: Common Toxicity Criteria (CTC) is a standardised classification of side effects used in assessing drugs for cancer therapy. Most US drug trials base their observations on this system which has a range of grades from 0-5, 5 usually equating to death. Currently version 3.0 is in use, released in 2003.

CompletenessLevel
type: Class
subclass of: Quality
subclass of: Restriction
  on property: isQualityOf
  on class: SurgicalProcedure
  min qualified cardinality: 0

Complication
type: Class
subclass of: Role
subclass of: Restriction
  on property: hasIdentifier
  on class: Name
  min qualified cardinality: 0
subclass of: Restriction
  on property: implementedBy
  on class: Process
  min qualified cardinality: 0

Computertomography
type: Class
subclass of: Imaging
subclass of: Restriction
  on property: hasParticipant
  on class: ChemicalSubstance
  min qualified cardinality: 0
disjoint with: MagneticResonanceImaging
disjoint with: RoentgenologicalImaging
disjoint with: Ultrasound

Consenting
type: Class
subclass of: AdministrativeProcess
subclass of: Restriction
  on property: isDeniedBy
  on class: HumanBeing
  min qualified cardinality: 0

CranialNerve
type: Class
subclass of: NeuralTreeOrgan
subclass of: Restriction
  on property: partOf
  some values from: SetOfCranialNerves
subclass of: Restriction
  on property: implements
  on class: Malfunction
  min qualified cardinality: 0

Criterion
type: Class
subclass of: Role
subclass of: Restriction
  on property: roleOf
  some values from: StateOfAffairs
subclass of: Restriction
  on property: roleOf
  all values from: StateOfAffairs
disjoint with: Drug
disjoint with: Implant
disjoint with: Marker
disjoint with: MeasurementUnit
disjoint with: ProfessionalRole
disjoint with: Therapy
comment: aka requirement; states of affairs play roles of criteria; how does one build a state of affairs in BFO?; probably reducible to quality and hasMeasurement--after all a state is the fact that some parameter has some value.... Food for further thought; for now it stays like this.

DCIS
type: Class
subclass of: NonInvasiveMammaryCarcinoma
disjoint with: LCIS
disjoint with: PagetNippleTumor
comment: Ductal Carcinoma In Situ, aka intraductal carcinoma

DHAPandARDHAPChemo
type: Class
subclass of: Chemotherapy
disjoint with: DeGramontChemo
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: DHAP is named after the drugs that are used in the treatment. This includes dexamethasone (pronounced decks-a-meth-a-sone), which is a steroid, and the chemotherapy drugs cytarabine (sigh-tare-a-been), which is sometimes called Ara C, and cisplatin (sis-pla-tin), which contains platinum. R-DHAP also includes the monoclonal antibody drug rituximab (Mabthera®).

Day
type: Class
subclass of: TemporalInterval
subclass of: Restriction
  on property: hasIntegerValue
  cardinality: 1
disjoint with: Hour
disjoint with: Minute
disjoint with: Month
disjoint with: Second
disjoint with: Week
disjoint with: Year

DeGramontChemo
type: Class
subclass of: Chemotherapy
disjoint with: DocetaxelCisplatinChemo
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: The 'de Gramont' regimen is named after the doctor who first used it and involves the drugs fluorouracil (pronounced floo-ro-you-ro-sill), also known as 5FU and folinic acid, which is also known as leucovorin (loo-co-vor-rin). This is a drug that makes 5FU more effective. The de Gramont regimen is one of several different ways of combining these two drugs and each has a different name. Some doctors in the UK use a version of the de Gramont regime known as modified de Gramont, because they feel it is easier to give and just as effective.

Deglutition
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: implements
  on class: Malfunction
  min qualified cardinality: 0

Depth
type: Class
subclass of: Length
disjoint with: Diameter
disjoint with: Height
disjoint with: Width
comment: ?

Diagnosis
type: Class
subclass of: Document
subclass of: Restriction
  on property: outcomeOf
  some values from: DiagnosticProcess
subclass of: Restriction
  on property: hasStringValue
  min cardinality: 0

DiagnosticProcess
type: Class
subclass of: MedicalProcess
subclass of: Restriction
  on property: undertakenBy
  some values from: HumanBeing
subclass of: Restriction
  on property: hasPart
  some values from: Class
    union of: Autopsy
    union of: ClinicalExamination
    union of: CytologicalExamination
    union of: HematologicalBiochemicalTest
    union of: HistologicalExamination
    union of: ImmunohistochemicalExamination
    union of: Process
disjoint with: TherapeuticProcess
comment: o ld name: DiagnosticProcedure

DifferentiationClass
type: Class
subclass of: TumorClass
comment: aka as Tumor Grade

Disease
type: Class
equivalent class: Restriction
  on property: realizedBy
  some values from: DiseaseProcess
subclass of: Disposition
subclass of: Restriction
  on property: disposition of
  all values from: Organism
subclass of: Restriction
  on property: diagnosedBy
  some values from: DiagnosticProcess
subclass of: Restriction
  on property: hasName
  on class: Name
  min qualified cardinality: 1
subclass of: Restriction
  on property: hasQuality
  on class: ICDClass
  max qualified cardinality: 1

DispatchingOfMedicalImage
type: Class
subclass of: DispatchingOfBiomedicalItem
subclass of: Restriction
  on property: hasReceptor
  on class: Object
  min qualified cardinality: 1
subclass of: Restriction
  on property: undergoneBy
  on class: MedicalImage
  min qualified cardinality: 1

DocetaxelCisplatinChemo
type: Class
subclass of: Chemotherapy
disjoint with: DoxorubicinIfosfamideChemo
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: The treatment involves two chemotherapy drugs, docetaxel (pronounced doe-se-tax-el), which is commonly known as Taxotere® (tax-oh-tare), and cisplatin (sis-pla-tin).

Document
type: Class
subclass of: InformationObject
subclass of: Restriction
  on property: undergoes
  on class: Signing
  min qualified cardinality: 0
subclass of: Restriction
  on property: signedBy
  on class: HumanBeing
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasPart
  all values from: Proposition
subclass of: Restriction
  on property: hasPart
  some values from: Proposition
disjoint with: Publication

Dose
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1
disjoint with: LVEF
disjoint with: LVSF
disjoint with: NumberOfCycles
disjoint with: PhysicalMagnitude
disjoint with: StressLevel
disjoint with: ToxicityLevel
disjoint with: pCRRate

DoseModulation
type: Class
equivalent class: Class
  union of: DoseIncrease
  union of: DoseReduction
subclass of: TherapeuticProcess
subclass of: Restriction
  on property: hasReason
  on class: Reason
  min qualified cardinality: 0
disjoint with: Pharmacotherapy
disjoint with: Radiotherapy

DoxorubicinIfosfamideChemo
type: Class
subclass of: Chemotherapy
disjoint with: E-CMFChemo
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: The treatment involves two chemotherapy drugs, doxorubicin (pronounced docks-o-rou-bi-sin) and ifosfamide (i-fos-fa-mide). You may sometimes hear this treatment being called AI after the drugs that are used (doxorubicin was originally called Adriamycin®). Other names for this treatment are Dox-Ifos and I-Ad.

E-CMFChemo
type: Class
subclass of: Chemotherapy
subclass of: Restriction
  on property: hasParticipant
  some values from: Epirubicin
disjoint with: ECChemo
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: E-CMF, which is also known as Epi-CMF, is named after the initials of the four chemotherapy drugs involved: epirubicin (pronounced epi-roo-biss-sin), cyclophosphamide (sigh-clo-fos-fa-mide), methotrexate (me-tho-trex-ate) and fluorouracil (floo-ro-you-ro-sill), which is also known as 5FU.

ECChemo
type: Class
subclass of: Chemotherapy
subclass of: Restriction
  on property: hasParticipant
  some values from: Epirubicin
disjoint with: ECFChemo
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: EC is named after the initials of the chemotherapy drugs used in the treatment, epirubicin (pronounced epi-roo-biss-sin) and cyclophosphamide (sigh-clo-fos-fa-mide).

ECFChemo
type: Class
subclass of: Chemotherapy
subclass of: Restriction
  on property: hasParticipant
  some values from: Epirubicin
disjoint with: ECXChemo
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: ECF is named after the initials of the chemotherapy drugs used, which are epirubicin (pronounced epi-roo-biss‑sin), cisplatin (sis-pla-tin) and fluorouracil (floo-ro-you-ro-sill), which is also known as 5FU.

ECG
type: Class
subclass of: DiagnosticProcess
subclass of: Restriction
  on property: undergoneBy
  some values from: Organism
subclass of: Restriction
  on property: reveals
  some values from: ESV
comment: German: EKG

ECOGPerformanceRating
type: Class
equivalent class: Class
  union of: ECOG0
  union of: ECOG1
  union of: ECOG2
  union of: ECOG3
  union of: ECOG4
  union of: ECOG5
subclass of: PerformanceRating
comment: aka the WHO or the Zubrod score

ECXChemo
type: Class
subclass of: Chemotherapy
subclass of: Restriction
  on property: hasParticipant
  some values from: Epirubicin
disjoint with: EEXChemo
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: ECX is named after the initials of the chemotherapy drugs used, which are epirubicin (pronounced epi-roo-biss-sin), cisplatin (sis-pla-tin) and capecitabine (kap-sight-a-been), which is also known as Xeloda® (ze-load-a).

EEXChemo
type: Class
subclass of: Chemotherapy
subclass of: Restriction
  on property: hasParticipant
  some values from: Epirubicin
disjoint with: ELFChemo
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: EEX is named after the initials of the drugs used, which are epirubicin (pronounced epi-roo-biss-sin), oxaliplatin (ox-ally-plat-in), which is also known as Eloxatin® (e-locks-a-tin) and capecitabine (kap-sight-a-been), also known as Xeloda® (ze-load-a).

ELFChemo
type: Class
subclass of: Chemotherapy
disjoint with: ESHAPandR-ESHAPChemo
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: ELF is named after the initials of the chemotherapy drugs used, which are etoposide (pronounced e-top-o-side), leucovorin (loo-co-vor-rin), which is also known as folinic acid, and fluorouracil (floo-ro-you-ro-cil), also known as 5FU.

ELISA
type: Class
subclass of: Immunostaining
disjoint with: FlowCytometry
disjoint with: IHC
disjoint with: ImmunoEM
disjoint with: WesternBlotting
comment: aka Enzyme-linked immunosorbent assay

ER
type: Class
subclass of: SexHormone
comment: An estrogen receptor (ER) is a nuclear receptor for estrogens such as estradiol (the main endogenous human estrogen). Estrogen receptors are intracellular proteins like other steroid hormone receptors.

ERT
type: Class
subclass of: HRT
comment: Estrogen Replacement Therapy

ESHAPandR-ESHAPChemo
type: Class
subclass of: Chemotherapy
disjoint with: EtoposideCisplatinChemo
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: ESHAP is named after the chemotherapy drugs used in the treatment, which are etoposide (pronounced e-top-o-side), methylprednisolone (me-thile-pred-ni-so-lone), which is a steroid, cytarabine (sigh-tare-a-been), which is sometimes known as Ara C and cisplatin (sis-pla-tin), which contains platinum. R-ESHAP also includes the drug rituximab (Mabthera®). Rituximab is a monoclonal antibody which is is used to treat several different types of B-cell non-Hodgkin's lymphoma. Monoclonal antibodies are used to try to destroy some types of cancer cells, while causing little harm to normal cells. They are designed to recognise and attach themselves (like a key in a lock) to certain proteins that are found on the surface of some cancer cells. This may then trigger the body’s immune system to attack the cancer cells and can sometimes cause the cells to destroy themselves. Rituximab locks onto a protein called CD20, which is found on the surface of one of the main types of normal white blood cells (B-cell lymphocytes). It is also present on the surface of most of the abnormal B-cell lymphocytes that occur in some types of non-Hodgkin's lymphoma. Rituximab acts by attacking both abnormal (malignant) and normal B-cell lymphocytes. However, the body can quite quickly replace any normal white blood cells that are damaged.

ESV
type: Class
subclass of: Volume
comment: End-systolic volume (ESV) is the volume of blood in the left ventricle at the end of contraction, or systole, and the beginning of filling, or diastole. End systolic volume can be used clinically as a measurement of the adequacy of cardiac emptying, related to systolic function.

EU-RHABIdentificationNumber
type: Class
subclass of: PatientIdentifier
comment: Identification Number according to the European Rhabdoid Study

EligibilityCriterion
type: Class
subclass of: Criterion
comment: aka inclusion criterion

Engraftment
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: hasOutcome
  some values from: Cell
comment: Def.: The Organismal Process of acceptence of new donor stem cells or bone marrow by an organism. The process is indicated by the production of new blood cells

EtoposideCisplatinChemo
type: Class
subclass of: Chemotherapy
disjoint with: FECChemo
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: The chemotherapy drugs used in this treatment are etoposide (pronounced e-top-o-side) and cisplatin (sis-pla-tin).

ExcisionalBiopsy
type: Class
subclass of: TotalTumorResection
comment: aka Tumorectomy; an "excisional biopsy" (sometimes called a "tumorectomy") is the removal of a tumor with a minimum of healthy tissue. It is therefore an excision rather than a biopsy.

ExtrapyramidalMotorSystem
type: Class
subclass of: Role
subclass of: Restriction
  on property: influencedBy
  on class: Malfunction
  min qualified cardinality: 0

FECChemo
type: Class
subclass of: Chemotherapy
disjoint with: GemCapChemo
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: FEC is named after the initials of the chemotherapy drugs used, which are fluorouracil (pronounced floo-ro-you-ro-sill), which is also known as 5FU, epirubicin (epi-roo-biss-sin) and cyclophosphamide (sigh-clo-fos-fa-mide).

FemaleHumanBeing
type: Class
subclass of: HumanBeing
subclass of: Restriction
  on property: hasGender
  some values from: Female
subclass of: Restriction
  on property: hasGender
  all values from: Female
subclass of: Restriction
  on property: undergoes
  on class: PartialHysterectomy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Hysterectomy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: TotalHysterectomy
  min qualified cardinality: 0

Fever
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: GeneralizedSymptom
  min qualified cardinality: 0
disjoint with: NightSweating

FillingInCaseReportForm
type: Class
subclass of: ClinicalDocumentation
subclass of: Restriction
  on property: undertakenBy
  on class: HumanBeing
  min qualified cardinality: 0

FineNeedleBiopsy
type: Class
subclass of: BiopsyWithoutIncision
disjoint with: PunchBiopsy
disjoint with: SurfaceBiopsy
disjoint with: TrucutBiopsy
comment: aka Aspiration or FNA biopsy

Fontanelle
type: Class
subclass of: SuturalJunction
subclass of: Restriction
  on property: undergoes
  on class: Bulging
  min qualified cardinality: 0

FreeLimb
type: Class
subclass of: LimbSegment
subclass of: Restriction
  on property: undergoes
  on class: Ataxia
  min qualified cardinality: 0

FreeLowerLimb
type: Class
subclass of: FreeLimb
subclass of: Restriction
  on property: implements
  on class: Monoparesis
  min qualified cardinality: 0

FreeUpperLimb
type: Class
subclass of: FreeLimb
subclass of: Restriction
  on property: implements
  on class: Monoparesis
  min qualified cardinality: 0

FuhrmanNuclearGrade
type: Class
subclass of: DifferentiationClass
disjoint with: GleasonDifferentiation
comment: used for kidney cancer

FurtherTherapy
type: Class
subclass of: Therapy
comment: NG: Further treatment in another clinic means, if a hospital makes the diagnosis of cancer and only starts to treat and then referes the patient to another hospital, then further treatment is given in another clinic. Further treatment can be protocol treatment and non-protocol treatment. E.g. it can be protocol treatment in another hospital but protocol treatment. But it can also be other treatment. It has to be specified in the CRFs comments.

G1
type: Class
subclass of: AJCDifferentiation
comment: Well-differentiated (Low grade)
type: Thing

G2
type: Class
subclass of: AJCDifferentiation
comment: Moderately differentiated (Intermediate grade)
type: Thing

G3
type: Class
subclass of: AJCDifferentiation
comment: Poorly differentiated (High grade)
type: Thing

G4
type: Class
subclass of: AJCDifferentiation
comment: Undifferentiated (High grade); undifferentiated = a term used to describe cells or tissues that do not have specialized ("mature") structures or functions. Undifferentiated cancer cells often grow and spread quickly.
type: Thing

GX
type: Class
subclass of: AJCDifferentiation
comment: Grade cannot be assessed (Undetermined grade)
type: Thing

GemCapChemo
type: Class
subclass of: Chemotherapy
disjoint with: GemCarboChemo
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: GemCap is named after the drugs used and involves the chemotherapy drugs: gemcitabine (pronounced jem-sight-a-been), which is also known as Gemzar® and capecitabine (cap-sight-a-been), also known as Xeloda® (ze-load-a).

GemCarboChemo
type: Class
subclass of: Chemotherapy
disjoint with: GemTaxolChemo
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: GemCarbo is named after the chemotherapy drugs used in the treatment, which are gemcitabine (pronounced gem-sight-a-been), which is also known as Gemzar® and carboplatin (car-bo-pla-tin).

GemTaxolChemo
type: Class
subclass of: Chemotherapy
disjoint with: GemicitabineCisplatinChemo
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: GemTaxol is named after the chemotherapy drugs used, which are gemcitabine (pronounced gem-sight-a-been), which is also known as Gemzar®, and paclitaxel (pak-li-tax-el), which is commonly called Taxol (tax-ol).

GemicitabineCisplatinChemo
type: Class
subclass of: Chemotherapy
disjoint with: IrinotecanWithDeGramontChemo
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: The treatment involves the two chemotherapy drugs gemcitabine (pronounced gem-sight-a-been), which is also known as Gemzar®, and cisplatin (sis-pla-tin).

GeneExpression
type: Class
subclass of: OrganismalProcess
disjoint with: Inflammation
disjoint with: Menopause
disjoint with: Menstruation
disjoint with: Pregnancy
disjoint with: Vomiting
comment: FMA?

GenomicType
type: Class
subclass of: TumorClass
comment: genomic type of a tumor

GleasonDifferentiation
type: Class
subclass of: DifferentiationClass
comment: used for prostate cancers; Gleason score = a system of grading prostate cancer tissue based on how it looks under a microscope. Gleason scores range from 2 to 10 and indicate how likely it is that a tumor will spread. A low Gleason score means the cancer tissue is similar to normal prostate tissue and the tumor is less likely to spread; a high Gleason score means the cancer tissue is very different from normal and the tumor is more likely to spread.

Glomerulopathy
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: UrinarySystemSymptom
  min qualified cardinality: 0

GnRHAnalog
type: Class
subclass of: HormoneTherapyDrug
disjoint with: LHRHAnalog
comment: GnRH = gonadotropin releasing hormone

GranulocyteColonyStimulatingFactor
type: Class
subclass of: ColonyStimulatingFactor
subclass of: Restriction
  on property: hasRole
  some values from: Hormone
disjoint with: LH-RH
comment: aka GCSF; Granulocyte Colony-Stimulating Factor (G-CSF or GCSF) is a hormone. It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to pulse them out of the marrow into the blood. It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils.

GrossMotorSkills
type: Class
subclass of: Quality
subclass of: Restriction
  on property: influencedBy
  on class: Malfunction
  min qualified cardinality: 0

HITChemotherapyRegime
type: Class
subclass of: ChemotherapyRegime
comment: Chemotherapy Regime according to the "Hirntumorstudien"

HRT
type: Class
subclass of: HormonalTreatment
disjoint with: LHRHAnalogTreatment
comment: Hormone Replacement Therapy (HRT) is medication containing one or more female hormones, commonly estrogen plus progestin (synthetic progesterone).

HbTest
type: Class
subclass of: HematologicalBiochemicalTest
subclass of: Restriction
  on property: reveals
  all values from: HemoglobinConcentration
subclass of: Restriction
  on property: reveals
  some values from: HemoglobinConcentration
comment: hemoglobin?

Headache
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0

Hearing
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: implements
  on class: Malfunction
  min qualified cardinality: 0

Heart
type: Class
subclass of: OrganWithCavitatedParts
subclass of: Restriction
  on property: undergoes
  on class: HeartFunctioning
  min qualified cardinality: 0

HeartFunctionGrade0
type: Class
subclass of: HeartFunctionGrade
disjoint with: HeartFunctionGrade1
disjoint with: HeartFunctionGrade2
disjoint with: HeartFunctionGrade3
disjoint with: HeartFunctionGrade4
comment: definition: Normal function, shortening fraction >30%

HeartFunctionGrade1
type: Class
subclass of: HeartFunctionGrade
disjoint with: HeartFunctionGrade2
disjoint with: HeartFunctionGrade3
disjoint with: HeartFunctionGrade4
comment: definition: Asymptomatic decline resting ejection fraction of >10% but <20% of baseline value, shortening fraction >25% but <30%

HeartFunctionGrade2
type: Class
subclass of: HeartFunctionGrade
disjoint with: HeartFunctionGrade3
disjoint with: HeartFunctionGrade4
comment: definition: Asymptomatic decline resting ejection fraction of >20% but <25% of baseline value, shortening fraction >20% but <25%

HeartFunctionGrade3
type: Class
subclass of: HeartFunctionGrade
disjoint with: HeartFunctionGrade4
comment: definiton: Congestive heart failure responsive to treatment, shortening fraction >15% but <20%

HeartFunctionGrade4
type: Class
subclass of: HeartFunctionGrade
comment: definition: Severe or refractory congestive heart failure or requiring intubation, shortening fraction <15%

HeartFunctioning
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: implements
  on class: Normality
  min qualified cardinality: 0
comment: The processes that implement the canonical functioning of the heart.

HeartRate
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1

HematologicalBiochemicalTest
type: Class
subclass of: DiagnosticProcess
subclass of: Restriction
  on property: undergoneBy
  some values from: Organism
disjoint with: HistologicalExamination
disjoint with: MacropathologicalExamination
disjoint with: PregnancyTest
disjoint with: SputumExam
disjoint with: Surveillance
disjoint with: UrineExam
comment: aka WBC

Hematuria
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: GeneralizedSymptom
  min qualified cardinality: 0

Hemiparesis
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0

HistologicalExamination
type: Class
subclass of: DiagnosticProcess
subclass of: Restriction
  on property: undergoneBy
  some values from: Organism
subclass of: Restriction
  on property: implements
  on class: JournalNumber
  min qualified cardinality: 0
subclass of: Restriction
  on property: reveals
  all values from: HistologicalType
subclass of: Restriction
  on property: undergoneBy
  some values from: MaterialOrganismalIndependentContinuant
disjoint with: MacropathologicalExamination
disjoint with: PregnancyTest
disjoint with: SputumExam
disjoint with: Surveillance
disjoint with: UrineExam

HistologicalSample
type: Class
subclass of: SubstanceSample
subclass of: Restriction
  on property: sampledFrom
  some values from: Organism
disjoint with: UrineSample
comment: sample of tissue sectioned as a thin slice

HistologicalType
type: Class
subclass of: TumorClass
comment: should have child HistopathologicalType?

Hour
type: Class
subclass of: TemporalInterval
subclass of: Restriction
  on property: hasIntegerValue
  cardinality: 1
disjoint with: Minute
disjoint with: Month
disjoint with: Second
disjoint with: Week
disjoint with: Year

HumanBeing
type: Class
equivalent class: Class
  union of: FemaleHumanBeing
  union of: MaleHumanBeing
subclass of: Organism
subclass of: Restriction
  on property: receives
  on class: PharmaceuticalSubstance
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasMagnitude
  on class: LanskyRating
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasSize
  some values from: BodySurfaceArea
subclass of: Restriction
  on property: undergoes
  on class: SubcutaneousMastectomy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Registration
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasMagnitude
  some values from: CardioPerformanceRating
subclass of: Restriction
  on property: participatesIn
  on class: ClinicalResearch
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: ClinicalExamination
  min qualified cardinality: 0
subclass of: Restriction
  on property: signs
  on class: ConsentForm
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasMagnitude
  some values from: Age
subclass of: Restriction
  on property: hasBloodPressure
  cardinality: 1
subclass of: Restriction
  on property: hasMagnitude
  on class: RFSDays
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasIdentifier
  on class: Address
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasRole
  on class: Class
    union of: AdministrativeRole
    union of: ProfessionalRole
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: PsychosocialCare
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasMagnitude
  on class: BodyMassIndex
  qualified cardinality: 1
subclass of: Restriction
  on property: hasIdentifier
  on class: Identifier
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasQuality
  on class: HeartRate
  qualified cardinality: 1
subclass of: Restriction
  on property: undergoes
  on class: Adenomastectomy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Chemotherapy
  min qualified cardinality: 0
subclass of: Restriction
  on property: patientAt
  on class: Hospital
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Brachytherapy
  min qualified cardinality: 0
subclass of: Restriction
  on property: fulfils
  on class: EligibilityCriterion
  min qualified cardinality: 0
subclass of: Restriction
  on property: denies
  on class: Consenting
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: PatientManagement
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasRelative
  min cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Immunotherapy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: DoseReduction
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: PartialMastectomy
  min qualified cardinality: 0
subclass of: Restriction
  on property: receives
  on class: Drug
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: GeneTherapy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Quadrantectomy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: BoostIrradiation
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasProgenitor
  cardinality: 1
subclass of: Restriction
  on property: hasQuality
  on class: CertaintyLevel
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Mastopexy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: TotalMastectomy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: NuclearImaging
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Lumpectomy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: PateyMastectomy
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasQuality
  on class: NumberOfLymphNodes
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: DoseIncrease
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasPart
  some values from: Breast
subclass of: Restriction
  on property: hasMagnitude
  some values from: ECOGPerformanceRating
subclass of: Restriction
  on property: hasMagnitude
  some values from: GeneralHealthRating
subclass of: Restriction
  on property: hasIdentifier
  on class: FullName
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: SegmentalMastectomy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: ChemotherapyCycle
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasRole
  on class: MedicalPractitioner
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: ReconstructiveBreastSurgery
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: AxillaryNodeDissection
  min qualified cardinality: 0

Hypertension
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: isFunctionalOrStructural
  has value: Functional
subclass of: Restriction
  on property: hasRole
  on class: VascularSymptom
  min qualified cardinality: 0
disjoint with: Hypotension
disjoint with: Thrombosis

Hypotension
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: isFunctionalOrStructural
  has value: Functional
subclass of: Restriction
  on property: hasRole
  on class: VascularSymptom
  min qualified cardinality: 0
disjoint with: Thrombosis

ICC
type: Class
subclass of: Immunostaining
disjoint with: IHC
comment: aka Immunocytochemistry; Immunocytochemistry differs from immunohistochemistry (IHC) in that the former is performed on samples of intact cells that have had most, if not all, their surrounding extracellular matrix removed.

ICEChemo
type: Class
subclass of: Chemotherapy
comment: Def. A chemotherapy based on Ifosfamide, Carboplatin and Etoposide.

IHC
type: Class
subclass of: Immunostaining
disjoint with: ImmunoEM
disjoint with: WesternBlotting
comment: aka Immunohistochemical staining

Identifier
type: Class
subclass of: InformationObject
subclass of: Restriction
  on property: hasStringValue
  cardinality: 1

Imaging
type: Class
subclass of: DiagnosticProcess
subclass of: Restriction
  on property: hasOutcome
  some values from: MedicalImage
subclass of: Restriction
  on property: pictures
  on class: OrganismalIndependentContinuant
  min qualified cardinality: 1

ImmuneDeficiency
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: GeneralizedSymptom
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasIdentifier
  on class: Name
  min qualified cardinality: 0

ImmunoEM
type: Class
subclass of: Immunostaining
disjoint with: WesternBlotting
comment: aka Immuno-electron microscopy

Immunoreaction
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: implements
  on class: Malfunction
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoneBy
  on class: Organism
  min qualified cardinality: 0

InfectionGrade0
type: Class
subclass of: InfectionGrade
comment: no infection

InfectionGrade1
type: Class
subclass of: InfectionGrade
comment: mild infection

InfectionGrade2
type: Class
subclass of: InfectionGrade
comment: medium infection; agent not identified

InfectionGrade3
type: Class
subclass of: InfectionGrade
comment: heavy infection; agent identified

InformationObject
type: Class
subclass of: GenericallyDependentContinuant
subclass of: Restriction
  on property: issuedBy
  on class: Object
  min qualified cardinality: 1
disjoint with: Institution

Institution
type: Class
subclass of: Object
subclass of: Restriction
  on property: participatesIn
  on class: ClinicalTrial
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasIdentifier
  some values from: TelephoneNumber
subclass of: Restriction
  on property: hasIdentifier
  on class: Address
  min qualified cardinality: 0
subclass of: Class
  complement of: Restriction
    on property: hasLaterality
    some values from: Laterality
subclass of: Restriction
  on property: hasName
  some values from: Name
subclass of: Restriction
  on property: hasIdentifier
  some values from: InstitutionIdentifier
comment: Best would be to replace "Institution hasIdentifier some InstitutionIdentifier" with "Institution hasIdentifier min 0 InstitutionIdentifier," however that is a QCR, and would probably generate OWL issues. As such, the constraint may be factually inaccurate, though certainly accurate and useful in ACGT context.

IntentionTremor
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0

IntracellReceptor
type: Class
subclass of: ReceptorProtein
comment: Intracellular receptors are receptors located inside the cell rather than on its cell membrane.

IntracranialPressure
type: Class
subclass of: Pressure
subclass of: Restriction
  on property: hasInfluenceOn
  on class: Symptom
  min qualified cardinality: 0

InvasiveDuctalCarcinoma
type: Class
subclass of: InvasiveMammaryCarcinoma
disjoint with: InvasiveLobularCarcinoma
disjoint with: MedullaryCarcinoma
disjoint with: TubularCarcinoma
comment: aka "no special type"

IrinotecanWithDeGramontChemo
type: Class
subclass of: Chemotherapy
disjoint with: MICChemo
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: This treatment involves the following chemotherapy drugs irinotecan (pronounced eye-ri-no-tee-can), fluorouracil (floo-ro-you-ro-sill), which is also known as 5FU, and a drug called folinic (fol-in-ic) acid, which is also known as leucovorin (loo-co-vor-rin). Folinic acid makes 5FU more effective. 5FU and folinic acid are commonly given together to treat bowel cancer. The combination of these two drugs can be given in different ways, and is often known as the 'de Gramont' regime, or modified de Gramont. When irinotecan is given with de Gramont it is sometimes called FOLFIRI. When irinotecan is given with modified de Gramont, it may be called IrMdG.

Isodose
type: Class
subclass of: TwoDimensionalRegion
comment: Def.: An isodose is a two-dimensional region (a surface or a line) that covers all point of the same energy dose or ionic dose.

JournalNumber
type: Class
subclass of: Identifier
subclass of: Restriction
  on property: implementedBy
  on class: HistologicalExamination
  min qualified cardinality: 1
comment: Number a pathologist assigns to a case. If more than on histologies of a single patient are examined, each histological specimen gets its own JournalNumber.

KarnofskyScore0
type: Class
subclass of: KarnofskyRating
disjoint with: KarnofskyScore10
disjoint with: KarnofskyScore100
disjoint with: KarnofskyScore20
disjoint with: KarnofskyScore30
disjoint with: KarnofskyScore40
disjoint with: KarnofskyScore50
disjoint with: KarnofskyScore60
disjoint with: KarnofskyScore70
disjoint with: KarnofskyScore80
disjoint with: KarnofskyScore90
comment: dead

KarnofskyScore10
type: Class
subclass of: KarnofskyRating
disjoint with: KarnofskyScore100
disjoint with: KarnofskyScore20
disjoint with: KarnofskyScore30
disjoint with: KarnofskyScore40
disjoint with: KarnofskyScore50
disjoint with: KarnofskyScore60
disjoint with: KarnofskyScore70
disjoint with: KarnofskyScore80
disjoint with: KarnofskyScore90
comment: moribund, rapidly progressive fatal disease processes

KarnofskyScore100
type: Class
subclass of: KarnofskyRating
disjoint with: KarnofskyScore20
disjoint with: KarnofskyScore30
disjoint with: KarnofskyScore40
disjoint with: KarnofskyScore50
disjoint with: KarnofskyScore60
disjoint with: KarnofskyScore70
disjoint with: KarnofskyScore80
disjoint with: KarnofskyScore90
comment: normal, no complaints, no signs of disease

KarnofskyScore20
type: Class
subclass of: KarnofskyRating
disjoint with: KarnofskyScore30
disjoint with: KarnofskyScore40
disjoint with: KarnofskyScore50
disjoint with: KarnofskyScore60
disjoint with: KarnofskyScore70
disjoint with: KarnofskyScore80
disjoint with: KarnofskyScore90
comment: very ill, urgently requiring admission, requires supportive measures or treatment

KarnofskyScore30
type: Class
subclass of: KarnofskyRating
disjoint with: KarnofskyScore40
disjoint with: KarnofskyScore50
disjoint with: KarnofskyScore60
disjoint with: KarnofskyScore70
disjoint with: KarnofskyScore80
disjoint with: KarnofskyScore90
comment: severely disabled, hospital admission indicated but no risk of death

KarnofskyScore40
type: Class
subclass of: KarnofskyRating
disjoint with: KarnofskyScore50
disjoint with: KarnofskyScore60
disjoint with: KarnofskyScore70
disjoint with: KarnofskyScore80
disjoint with: KarnofskyScore90
comment: disabled, requires special care and help

KarnofskyScore50
type: Class
subclass of: KarnofskyRating
disjoint with: KarnofskyScore60
disjoint with: KarnofskyScore70
disjoint with: KarnofskyScore80
disjoint with: KarnofskyScore90
comment: requires help often, requires frequent medical care

KarnofskyScore60
type: Class
subclass of: KarnofskyRating
disjoint with: KarnofskyScore70
disjoint with: KarnofskyScore80
disjoint with: KarnofskyScore90
comment: requiring some help, can take care of most personal requirements

KarnofskyScore70
type: Class
subclass of: KarnofskyRating
disjoint with: KarnofskyScore80
disjoint with: KarnofskyScore90
comment: caring for self, not capable of normal activity or work

KarnofskyScore80
type: Class
subclass of: KarnofskyRating
disjoint with: KarnofskyScore90
comment: normal activity with some difficulty, some symptoms or signs

KarnofskyScore90
type: Class
subclass of: KarnofskyRating
comment: capable of normal activity, few symptoms or signs of disease

Kidney
type: Class
subclass of: CorticomedullaryOrgan
subclass of: Restriction
  on property: hasProperPart
  some values from: RenalSegment
subclass of: Restriction
  on property: undergoes
  on class: KidneyFunctioning
  min qualified cardinality: 0

KidneyFunctioning
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: implements
  on class: Normality
  min qualified cardinality: 0
comment: The processes that implement the canonical functioning of the kidney.

LH-RH
type: Class
subclass of: BiologicalMacromolecule
subclass of: Restriction
  on property: hasRole
  some values from: Hormone
comment: LH-RH means Luteinizing Hormone-Releasing Hormone. It is a Releasing hormone, i.e. a hormone whose main purpose is to control the release of another hormone, here the Luteinizing hormone.

LVEF
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1
disjoint with: LVSF
disjoint with: NumberOfCycles
disjoint with: PhysicalMagnitude
disjoint with: StressLevel
disjoint with: ToxicityLevel
disjoint with: pCRRate
comment: Left Ventricular Ejection Fraction

LVSF
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1
disjoint with: NumberOfCycles
disjoint with: PhysicalMagnitude
disjoint with: StressLevel
disjoint with: ToxicityLevel
disjoint with: pCRRate
comment: Shortening Fraction Of The Left Ventricle

LanskyScore0
type: Class
subclass of: LanskyRating
disjoint with: LanskyScore10
disjoint with: LanskyScore100
disjoint with: LanskyScore20
disjoint with: LanskyScore30
disjoint with: LanskyScore40
disjoint with: LanskyScore50
disjoint with: LanskyScore60
disjoint with: LanskyScore70
disjoint with: LanskyScore80
disjoint with: LanskyScore90
comment: unresponsive

LanskyScore10
type: Class
subclass of: LanskyRating
disjoint with: LanskyScore100
disjoint with: LanskyScore20
disjoint with: LanskyScore30
disjoint with: LanskyScore40
disjoint with: LanskyScore50
disjoint with: LanskyScore60
disjoint with: LanskyScore70
disjoint with: LanskyScore80
disjoint with: LanskyScore90
comment: doesn't play; does not get out of bed

LanskyScore100
type: Class
subclass of: LanskyRating
disjoint with: LanskyScore20
disjoint with: LanskyScore30
disjoint with: LanskyScore40
disjoint with: LanskyScore50
disjoint with: LanskyScore60
disjoint with: LanskyScore70
disjoint with: LanskyScore80
disjoint with: LanskyScore90
comment: fully active, normal

LanskyScore20
type: Class
subclass of: LanskyRating
disjoint with: LanskyScore30
disjoint with: LanskyScore40
disjoint with: LanskyScore50
disjoint with: LanskyScore60
disjoint with: LanskyScore70
disjoint with: LanskyScore80
disjoint with: LanskyScore90
comment: sleeping often; play entirely limited to very passive activities

LanskyScore30
type: Class
subclass of: LanskyRating
disjoint with: LanskyScore40
disjoint with: LanskyScore50
disjoint with: LanskyScore60
disjoint with: LanskyScore70
disjoint with: LanskyScore80
disjoint with: LanskyScore90
comment: bedbound; needing assistance even for quiet play

LanskyScore40
type: Class
subclass of: LanskyRating
disjoint with: LanskyScore50
disjoint with: LanskyScore60
disjoint with: LanskyScore70
disjoint with: LanskyScore80
disjoint with: LanskyScore90
comment: mainly in bed; participates in quiet activities

LanskyScore50
type: Class
subclass of: LanskyRating
disjoint with: LanskyScore60
disjoint with: LanskyScore70
disjoint with: LanskyScore80
disjoint with: LanskyScore90
comment: lying around much of the day, but gets dressed; no active playing participates in all quiet play and activities

LanskyScore60
type: Class
subclass of: LanskyRating
disjoint with: LanskyScore70
disjoint with: LanskyScore80
disjoint with: LanskyScore90
comment: up and around, but active play minimal; keeps busy by being involved in quieter activities

LanskyScore70
type: Class
subclass of: LanskyRating
disjoint with: LanskyScore80
disjoint with: LanskyScore90
comment: greater restriction of play and less time spent in play activity

LanskyScore80
type: Class
subclass of: LanskyRating
disjoint with: LanskyScore90
comment: active, but tired more quickly

LanskyScore90
type: Class
subclass of: LanskyRating
comment: minor restrictions in strenuous physical activity

Length
type: Class
subclass of: PhysicalMagnitude
disjoint with: Pressure
disjoint with: SurfaceSize
disjoint with: Weight
comment: ?

Limb
type: Class
subclass of: CardinalBodyPart
subclass of: Restriction
  on property: implements
  on class: Ataxia
  min qualified cardinality: 0

LinearParticleAccelerator
type: Class
subclass of: TechnicalObject
subclass of: Restriction
  on property: participatesIn
  on class: Radiotherapy
  min qualified cardinality: 0

LongitudinalIncision
type: Class
subclass of: SurgicalApproach
disjoint with: ThoracoAbdominalApproach
disjoint with: TransversalApproach
comment: Längsschnitt?

LostToFollowUp
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: undergoneBy
  on class: HumanBeing
  min qualified cardinality: 0

LowCertainty
type: Class
subclass of: CertaintyLevel
subclass of: Restriction
  on property: isQualityOf
  on class: HumanBeing
  min qualified cardinality: 0

Lung
type: Class
subclass of: LobularOrgan
subclass of: Restriction
  on property: undergoes
  on class: Lobectomy
  min qualified cardinality: 0

LymphNode
type: Class
subclass of: OrganComponent
subclass of: Restriction
  on property: hasQuality
  on class: Regionality
  min qualified cardinality: 0

LymphNodeDissection
type: Class
subclass of: SurgicalOperation
subclass of: Restriction
  on property: hasParticipant
  on class: LymphNode
  min qualified cardinality: 0

M0
type: Class
subclass of: MClass
disjoint with: M1
disjoint with: MX
comment: definition: No distant metastasis

M1
type: Class
subclass of: MClass
disjoint with: MX
comment: definition: Distant metastasis (includes metastasis to ipsilateral supraventricular lymph node[s])

MClass
type: Class
equivalent class: Class
  union of: M0
  union of: M1
  union of: MX
subclass of: ClinicalClassTNM
comment: definition: Distant metastasis classification

MICChemo
type: Class
subclass of: Chemotherapy
disjoint with: MMChemo
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: MIC is named after the initials of the chemotherapy drugs used, which are mitomycin (pronounced my-toe-my-sin), ifosfamide (i-foss-fa-mide) and cisplatin (sis-pla-tin).

MMChemo
type: Class
subclass of: Chemotherapy
disjoint with: MMMChemo
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: MM is named after the initials of the chemotherapy drugs used, which are methotrexate (pronounced me-tho-trex-ate) and mitoxantrone (my-toe-zan-trone). Sometimes the term MM may be used to describe a combination of mitomycin and mitoxantrone. Our cancer support service nurses can give you further information about this regimen.

MMMChemo
type: Class
subclass of: Chemotherapy
disjoint with: MVPChemo
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: MMM is named after the initials of the chemotherapy drugs used, which are mitomycin (pronounced my-toe-my-sin), methotrexate (me-tho-trex-ate) and mitozantrone (my-toe-zan-trone).

MRT
type: Class
subclass of: RhabdoidTumor
comment: Rhabdoid tumor in soft tissue (except kidney) MRT is short for Malign Rhabdoid Tumor

MVPChemo
type: Class
subclass of: Chemotherapy
disjoint with: MayoChemo
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: MVP is named after the chemotherapy drugs used in the treatment, which are mitomycin (pronounced my-toe-my-sin), vinblastine (vin-blas-teen) and cisplatin (sis-pla-tin).

MX
type: Class
subclass of: MClass
comment: definition: Presence of distant metastasis cannot be assessed

MagneticResonanceImaging
type: Class
subclass of: Imaging
subclass of: Restriction
  on property: hasParticipant
  on class: ChemicalSubstance
  min qualified cardinality: 0
disjoint with: RoentgenologicalImaging
disjoint with: Ultrasound

Malfunction
type: Class
subclass of: Quality
subclass of: Restriction
  on property: hasName
  on class: Name
  min qualified cardinality: 1
subclass of: Restriction
  on property: implementedBy
  on class: NeuroendocrinologicalProcess
  min qualified cardinality: 0
subclass of: Restriction
  on property: implementedBy
  on class: SetOfCranialNerves
  min qualified cardinality: 0
subclass of: Restriction
  on property: implementedBy
  on class: CranialNerve
  min qualified cardinality: 0
subclass of: Restriction
  on property: implementedBy
  on class: TubulesFunctioning
  min qualified cardinality: 0
subclass of: Restriction
  on property: implementedBy
  on class: MotoricCoordination
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasInfluenceOn
  on class: ExtrapyramidalMotorSystem
  min qualified cardinality: 0
subclass of: Restriction
  on property: implementedBy
  on class: VegetativeFunctioning
  min qualified cardinality: 0
subclass of: Restriction
  on property: implementedBy
  on class: NeuropsychologicalProcess
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasInfluenceOn
  on class: GrossMotorSkills
  min qualified cardinality: 0
subclass of: Restriction
  on property: implementedBy
  on class: Hearing
  min qualified cardinality: 0

MalignNeoplasm
type: Class
subclass of: Neoplasm
subclass of: Restriction
  on property: causes
  some values from: Symptom
subclass of: Restriction
  on property: regionalRecurrenceOf
  min cardinality: 0
subclass of: Restriction
  on property: implements
  on class: SecondaryMalignTumor
  min qualified cardinality: 0
subclass of: Restriction
  on property: relapseOf
  min cardinality: 0
subclass of: Restriction
  on property: hasDistantRecurrence
  min cardinality: 0
subclass of: Restriction
  on property: hasRelapse
  min cardinality: 0
subclass of: Restriction
  on property: hasLocalRecurrence
  min cardinality: 0
subclass of: Restriction
  on property: relapseOf
  all values from: MalignNeoplasm
subclass of: Restriction
  on property: hasRegionalRecurrence
  min cardinality: 0
subclass of: Restriction
  on property: hasMalignancy
  some values from: Class
    one of: IntermediateMalignancy
    one of: LowMalignancy
    one of: HighMalignancy
subclass of: Restriction
  on property: localRecurrenceOf
  min cardinality: 0
subclass of: Restriction
  on property: distantRecurrenceOf
  min cardinality: 0
disjoint with: SemiMalignNeoplasm

Malignancy
type: Class
equivalent class: Class
  one of: IntermediateMalignancy
  one of: NoMalignancy
  one of: LowMalignancy
  one of: HighMalignancy
subclass of: Quality
subclass of: Restriction
  on property: hasIdentifier
  on class: Name
  min qualified cardinality: 0

MammaryCarcinoma
type: Class
subclass of: Carcinoma
subclass of: Restriction
  on property: hasTumorClass
  on class: MammaryCarcinomaClass
  min qualified cardinality: 1
disjoint with: RenalCellCarcinoma

Marker
type: Class
subclass of: Role
disjoint with: MeasurementUnit
disjoint with: ProfessionalRole
disjoint with: Therapy
comment: aka indicator

Mask
type: Class
subclass of: TechnicalObject
subclass of: Restriction
  on property: participatesIn
  on class: Radiotherapy
  min qualified cardinality: 0

MaterialOrganismalIndependentContinuant
type: Class
subclass of: OrganismalIndependentContinuant
subclass of: Restriction
  on property: hasMagnitude
  on class: Circumference
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasDiameter
  on class: Diameter
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasWeight
  on class: Weight
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasHeight
  on class: Height
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasQuality
  on class: Volume
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasWidth
  on class: Width
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasLength
  on class: Length
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasDepth
  on class: Depth
  min qualified cardinality: 0

MayoChemo
type: Class
subclass of: Chemotherapy
disjoint with: Oxaliplatin5FUChemo
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: The Mayo regime (named after the hospital that started it) involves the drugs fluorouracil (pronounced floo-ro-you-ro-sill), which is a chemotherapy drug sometimes known as 5FU, and folinic (fol-in-ic) acid, which is a drug that makes 5FU more effective. It is also known as leucovorin (loo-co-vor-rin) or LV. 5FU and folinic acid are commonly used in the treatment of bowel cancer. It is important to know that the two drugs are often used together in different ways. This information is specifically about the Mayo regimen.

MedicalExpertIdentifier
type: Class
subclass of: Identifier
disjoint with: PatientIdentifier
disjoint with: RegistryIdentifier
disjoint with: TelephoneNumber
comment: doctor´s name

MedicalHistory
type: Class
subclass of: History
subclass of: Class
  union of: PathologicalFormation
  union of: Restriction
    on property: describes
    on class: Disease
    min qualified cardinality: 0

MedicalImage
type: Class
subclass of: Image
subclass of: Restriction
  on property: participatesIn
  on class: RadiotherapyPlanning
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: DispatchingOfMedicalImage
  min qualified cardinality: 0
subclass of: Restriction
  on property: outcomeOf
  all values from: Imaging

MedicalProcess
type: Class
equivalent class: Class
  union of: DiagnosticProcess
  union of: TherapeuticProcess
subclass of: IntentionalProcess
subclass of: Restriction
  on property: hasPlace
  on class: Institution
  min qualified cardinality: 1
subclass of: Restriction
  on property: promptedBy
  on class: ProcessualEntity
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasAgent
  some values from: HumanBeing
subclass of: Restriction
  on property: hasParticipant
  some values from: Organism
subclass of: Restriction
  on property: followUpOf
  min cardinality: 0
subclass of: Restriction
  on property: hasIdentifier
  on class: Identifier
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasPatient
  min cardinality: 1
subclass of: Restriction
  on property: hasQuality
  on class: Toxicity
  min qualified cardinality: 0
subclass of: Restriction
  on property: undertakenBy
  min cardinality: 1
subclass of: Restriction
  on property: hasFollowUp
  min cardinality: 0

MesenteryOfLargeIntestine
type: Class
subclass of: PeritonealMesentery
comment: Synonym: Mesocolon

Methotrexat
type: Class
subclass of: PharmaceuticalSubstance
subclass of: Restriction
  on property: implements
  some values from: Cytostatic
comment: Abbr. MTX 2-Desoxy-4-amino-10-methyl folic acid

Microarray
type: Class
subclass of: ObjectAggregate
subclass of: Restriction
  on property: hasIdentifier
  cardinality: 1

Minute
type: Class
subclass of: TemporalInterval
subclass of: Restriction
  on property: hasIntegerValue
  cardinality: 1
disjoint with: Month
disjoint with: Second
disjoint with: Week
disjoint with: Year

Misscarriage
type: Class
subclass of: OrganismalProcess
comment: = spontaneous abortion

Monoparesis
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: undergoneBy
  on class: FreeLimb
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0

Month
type: Class
subclass of: TemporalInterval
subclass of: Restriction
  on property: hasIntegerValue
  cardinality: 1
disjoint with: Second
disjoint with: Week
disjoint with: Year

MotoricCoordination
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: implements
  on class: Malfunction
  min qualified cardinality: 0

Myalgia
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: MusculoskeletalSystemSymptom
  min qualified cardinality: 0

N0
type: Class
equivalent class: NodalStatusNegative
subclass of: NClass
disjoint with: N1
disjoint with: NX
comment: definition: No regional lymph node metastasis

N1
type: Class
subclass of: NClass
disjoint with: NX
comment: definition: Metastasis to movable ipsilateral axillary lymph node(s)

N2
type: Class
equivalent class: Class
  union of: N2a
  union of: N2b
subclass of: NClass
comment: definition: Metastasis to ipsilateral axillary lymph node(s) fixed to one another or to other structures

N2a
type: Class
subclass of: N2
disjoint with: N2b
comment: definition: Metastasis or Metastases to ipsilateral axillary lymph node(s) fixed to one another or to other structures

N2b
type: Class
subclass of: N2
comment: definition: Metastasis or Metastases to ipsilateral axillary lymph node(s) along the Arteria mammaria interna without clinically identifiable axillary lymph node metastases

N3
type: Class
equivalent class: Class
  union of: N3a
  union of: N3b
  union of: N3c
subclass of: NClass
comment: definition: Metastasis to ipsilateral internal mammary lymph node(s)

N3a
type: Class
subclass of: N3
disjoint with: N3b
disjoint with: N3c
comment: definition: Metastasis or Metastases to ipsilateral infraclaviculary lymph node(s)

N3b
type: Class
subclass of: N3
disjoint with: N3c
comment: definition: Metastasis or Metastases to ipsilateral lymph node(s) along the Arteria mammaria with axillary lymph node metastases

N3c
type: Class
subclass of: N3
comment: definition: Metastasis or Metastases in ipsilateral supraclaviculary lymph node(s)

NClass
type: Class
equivalent class: Class
  union of: N0
  union of: N1
  union of: N2
  union of: N3
  union of: NX
subclass of: ClinicalClassTNM
comment: definition: Regional lymph node metastasis classification

NX
type: Class
subclass of: NClass
comment: definition: Regional lymph nodes cannot be assessed (eg, previously removed)

Nadir
type: Class
subclass of: Role
comment: Def.: The role of the lowest measurement, e.g. of number of erythrocytes or thrombocytes.

Name
type: Class
equivalent class: Class
  union of: FirstName
  union of: FullName
  union of: LastName
subclass of: Identifier
subclass of: Restriction
  on property: hasStringValue
  cardinality: 1

Nausea
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: AlimentarySystemSymptom
  min qualified cardinality: 0

NeoadjuvantTherapy
type: Class
subclass of: SupportingTherapy
comment: Def.: Treatment that's given first to help make the next treatment step go more smoothly. For example, chemotherapy, radiation or hormones may be given before surgery. In breast cancer, this therapy is mainly used to shrink a large tumor so that it's easier to take out.

Neoplasm
type: Class
equivalent class: Class
  union of: BenignNeoplasm
  union of: MalignNeoplasm
  union of: SemiMalignNeoplasm
subclass of: PathologicalFormation
subclass of: Restriction
  on property: hasQuality
  on class: TumorSituation
  qualified cardinality: 1
subclass of: Restriction
  on property: implements
  on class: SecondaryTumor
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasMetastasis
  on class: Metastasis
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasMalignancy
  some values from: Malignancy
subclass of: Restriction
  on property: undergoes
  on class: TumorDevelopment
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasQuality
  on class: TumorHomogeneity
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasQuality
  on class: TumorClass
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasQuality
  on class: VitalityLevel
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: TumorResection
  min qualified cardinality: 0
comment: aka tumor

Nephroblastoma
type: Class
equivalent class: Class
  union of: HighRiskNephroblastoma
  union of: IntermediateRiskNephroblastoma
  union of: LowRiskNephroblastoma
subclass of: DysontogeneticTumor
subclass of: Restriction
  on property: partOf
  some values from: Kidney
subclass of: Restriction
  on property: hasTumorClass
  on class: WilmsTumorStage
  qualified cardinality: 1
subclass of: Restriction
  on property: hasQuality
  on class: NephroblastomaSpread
  min qualified cardinality: 0

NephroblastomaSpread
type: Class
subclass of: Quality
subclass of: Restriction
  on property: isQualityOf
  on class: Nephroblastoma
  min qualified cardinality: 0

Neuraxis
type: Class
subclass of: OrganWithOrganCavity
comment: Syn.: Central Nervous System

NeuroendocrinologicalProcess
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: implements
  on class: Malfunction
  min qualified cardinality: 0

NeuropsychologicalProcess
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: implements
  on class: Malfunction
  min qualified cardinality: 0

NightSweating
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: hasRole
  on class: GeneralizedSymptom
  min qualified cardinality: 0

NonInvasiveMammaryCarcinoma
type: Class
subclass of: MammaryCarcinoma
comment: Non-invasive aka "in situ"

Normality
type: Class
subclass of: Quality
subclass of: Restriction
  on property: isQualityOf
  on class: OrganismalIndependentContinuant
  min qualified cardinality: 0

NumberOfBloodCells
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1

NumberOfCycles
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1
disjoint with: PhysicalMagnitude
disjoint with: StressLevel
disjoint with: ToxicityLevel
disjoint with: pCRRate

NumberOfLatenessDays
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1

NumberOfLymphNodes
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1

NumberOfStemCells
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1

Nystagmus
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0

OlfactoryNerve
type: Class
subclass of: SegmentOfNeuralTreeOrgan
subclass of: Restriction
  on property: implements
  on class: CranialNerveNumber
  qualified cardinality: 1

Organism
type: Class
subclass of: BiologicalIndependentContinuant
subclass of: Restriction
  on property: undergoes
  on class: SurgicalSuture
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: ConeBiopsy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Infection
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: SurfaceBiopsy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Diarrhea
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: SuctionAssistedCoreBiopsy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: SurgicalOperation
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasHistory
  on class: History
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: FineNeedleBiopsy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: EndoscopicBiopsy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Coughing
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasRole
  on class: Patient
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: DoseModulation
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: SurgicalProcedure
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasMagnitude
  on class: NumberOfTumors
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasPart
  some values from: OrganismalIndependentContinuant
subclass of: Restriction
  on property: hasPartNeoplasm
  on class: Neoplasm
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Labor
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasName
  on class: Name
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Menstruation
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: PunchBiopsy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: TrucutBiopsy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undertakes
  on class: Process
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  some values from: Metabolism
subclass of: Restriction
  on property: hasRole
  on class: RelativeRole
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Immunoreaction
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: CoreNeedleBiopsy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Vomiting
  min qualified cardinality: 0
subclass of: Restriction
  on property: providesSample
  on class: SubstanceSample
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasDeath
  on class: Death
  qualified cardinality: 1
subclass of: Restriction
  on property: undergoes
  on class: InducedAbortion
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Radiotherapy
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Pregnancy
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasNumberOfSiblings
  some values from: int
subclass of: Restriction
  on property: hasBirthDate
  some values from: date
subclass of: Restriction
  on property: undergoes
  some values from: Life
subclass of: Restriction
  on property: undergoes
  on class: MedicalProcess
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Pharmacotherapy
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasBirth
  on class: Birth
  qualified cardinality: 1
subclass of: Restriction
  on property: undergoes
  on class: Lactation
  min qualified cardinality: 0
subclass of: Restriction
  on property: receives
  on class: ColonyStimulatingFactor
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Misscarriage
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Menopause
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Lobectomy
  min qualified cardinality: 0
disjoint with: OrganismalIndependentContinuant

OrganismalIndependentContinuant
type: Class
equivalent class: Class
  union of: ImmaterialOrganismalIndependentContinuant
  union of: MaterialOrganismalIndependentContinuant
subclass of: BiologicalIndependentContinuant
subclass of: Restriction
  on property: implements
  on class: RadiotherapyRiskOrgan
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: Infection
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasLaterality
  cardinality: 1
subclass of: Restriction
  on property: hasQuality
  on class: NumberOfTumors
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasIdentifier
  on class: Identifier
  min qualified cardinality: 0
subclass of: Restriction
  on property: picturedBy
  on class: Imaging
  min qualified cardinality: 0
subclass of: Restriction
  on property: partOf
  some values from: Organism

Oxaliplatin5FUChemo
type: Class
subclass of: Chemotherapy
disjoint with: PCVChemo
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: The treatment involves two chemotherapy drugs, which are oxaliplatin (pronounced ox-ali-plat-in) and 5FU, which is also known as fluorouracil (floo-ro-you-ro-sill). They are given with a vitamin called folinic acid (leucovorin), which makes 5FU more effective. This combination of chemotherapy is sometimes referred to as the FOLFOX regimen, named after the drugs used. Some doctors may refer to the combination as oxaliplatin modified deGramont (OxMdG), when they give the drugs in a different order.

PCR
type: Class
subclass of: DNAReplication
comment: aka Gene Amplification

PCVChemo
type: Class
subclass of: Chemotherapy
disjoint with: PMitCEBOChemo
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: PCV is named after the initials of the chemotherapy drugs used, which are procarbazine (pronounced pro-car-ba-zeen), lomustine (low-mus-teen), which is also known as CCNU®, and vincristine (vin-chris-teen).

PMitCEBOChemo
type: Class
subclass of: Chemotherapy
disjoint with: PaclitaxelCarboplatinChemo
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: PMitCEBO is named after the initials of the drugs used, which are prednisolone (pronounced pred-ni-so-lone), which is a steroid, and the following chemotherapy drugs: mitoxantrone (my-toe-zan-trone), cyclophosphamide (sigh-clo-fos-fa-mide), etoposide (e-top-o-side), bleomycin (blee-o-my-sin) and vincristine (vin-chris-teen), which used to be known as Oncovin©.

PR
type: Class
subclass of: SexHormone
comment: The progesterone receptor (PR) is an intracellular steroid receptor that specifically binds progesterone.

PRStatus
type: Class
subclass of: TumorClass
comment: aka Progesterone Receptor Status

PaclitaxelCarboplatinChemo
type: Class
subclass of: Chemotherapy
disjoint with: PemetrexedCisplatinChemo
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: The treatment involves the two chemotherapy drugs paclitaxel (pronounced pak-li-tax-el), which is commonly known as Taxol, and carboplatin (car-bo-pla-tin).

Papilledema
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0

Paraparesis
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0

Paraplegia
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasPlace
  on class: Vertebra
  qualified cardinality: 1

Parturition
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: undergoneBy
  some values from: FemaleHumanBeing
comment: = the actual process of giving birth; labor+delivery

PathologicClasspTNM
type: Class
equivalent class: Class
  union of: pMClass
  union of: pNClass
  union of: pTClass
subclass of: MammaryCarcinomaClass
comment: Pathological classification (Postsurgical histopathological classification), designated pTNM. This is based on the evidence acquired before treatment, supplemented or modified by the additional evidence acquired from surgery and from pathological examination. The pathological assessment of the primary tumour (pT) entails a resection of the primary tumour or biopsy adequate to evaluate the highest pT category. The pathological assessment of the regional lymph nodes (pN) entails removal of nodes adequate to validate the absence of regional lymph node metastasis (pN0) and sufficient to evaluate the highest pN category. The pathological assessment of distant metastasis (pM) entails microscopic examination.

PathologicalFormation
type: Class
subclass of: MaterialOrganismalIndependentContinuant
subclass of: Restriction
  on property: locatedIn
  some values from: CanonicalMaterialOrganismalIndependentContinuant
comment: Def.: A MaterialOrganismalIndependentContiuant whic is not part of the canonical body.

PatientAdmission
type: Class
subclass of: PatientManagement
subclass of: Restriction
  on property: hasReason
  on class: ReasonOfAdmission
  min qualified cardinality: 0

PatientEnrollment
type: Class
subclass of: PatientManagement
subclass of: Restriction
  on property: hasReason
  on class: ReasonForPatientEnrollment
  min qualified cardinality: 0

PatientManagement
type: Class
subclass of: AdministrativeProcess
subclass of: Restriction
  on property: undertakenBy
  on class: HumanBeing
  min qualified cardinality: 1
subclass of: Restriction
  on property: undergoneBy
  on class: HumanBeing
  min qualified cardinality: 1

PemetrexedCisplatinChemo
type: Class
subclass of: Chemotherapy
disjoint with: TACChemo
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: The treatment involves the two chemotherapy drugs pemetrexed (pronounced pem-a-trex-ed), which is also known as Alimta®, and cisplatin (sis-pla-tin).

PharmaceuticalSubstance
type: Class
subclass of: ChemicalSubstance
subclass of: Restriction
  on property: participatesIn
  on class: TherapeuticProcess
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasMagnitude
  on class: Dose
  min qualified cardinality: 0

Pharmacotherapy
type: Class
subclass of: TherapeuticProcess
subclass of: Restriction
  on property: hasParticipant
  on class: Cobalt-60
  min qualified cardinality: 0
subclass of: Restriction
  on property: implements
  on class: PharmacotherapyRegime
  min qualified cardinality: 0
disjoint with: Radiotherapy

PharmacotherapyCycle
type: Class
subclass of: TreatmentCycle
subclass of: Restriction
  on property: partOf
  some values from: Pharmacotherapy
subclass of: Restriction
  on property: hasParticipant
  on class: PharmaceuticalSubstance
  min qualified cardinality: 1

PharmacotherapyRegime
type: Class
subclass of: Design
subclass of: Restriction
  on property: implementedBy
  on class: Pharmacotherapy
  min qualified cardinality: 0

PhysicalMagnitude
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasFloatValue
  cardinality: 1
disjoint with: StressLevel
disjoint with: ToxicityLevel
disjoint with: pCRRate

PituitaryGland
type: Class
subclass of: LobularOrgan
comment: Syn.: Hypophysis

PlasterFrame
type: Class
subclass of: TechnicalObject
subclass of: Restriction
  on property: participatesIn
  on class: Radiotherapy
  min qualified cardinality: 0

Platelet
type: Class
subclass of: NonNucleatedSolocyte
comment: Synonym: Thrombocyte

PortionOfSoftTissue
type: Class
subclass of: FiatObjectPart
comment: Def.: The portion of tissue of a body that does not contain bones or bonelike material.

PreClinicalResearch
type: Class
subclass of: AdministrativeProcess
subclass of: Restriction
  on property: undertakenBy
  min cardinality: 1
disjoint with: ProtocolChange
disjoint with: Registration

PregnancyStatus
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasBooleanValue
  cardinality: 1

ProcessEnd
type: Class
subclass of: ProcessBoundary
subclass of: Restriction
  on property: hasReason
  on class: Reason
  min qualified cardinality: 0
disjoint with: ProcessStart

ProcessOrigin
type: Class
subclass of: Quality
subclass of: Restriction
  on property: isQualityOf
  on class: Process
  min qualified cardinality: 0

Proteinuria
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: GeneralizedSymptom
  min qualified cardinality: 0

Protocol
type: Class
subclass of: Document
subclass of: Restriction
  on property: implementedBy
  on class: TherapeuticProcess
  min qualified cardinality: 0
disjoint with: Questionnaire
comment: I'd rather put this one under Processes.

PsychosocialCare
type: Class
subclass of: CareProcess
subclass of: Restriction
  on property: hasPatient
  on class: HumanBeing
  min qualified cardinality: 1

PulmonaryEdema
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: RespiratorySystemSymptom
  min qualified cardinality: 0

Purging
type: Class
subclass of: TherapeuticProcess
subclass of: Restriction
  on property: undergoneBy
  some values from: SubstanceSample
comment: A process of cleaining a biomedical sample of e.g. tumor cells.

R0
type: Class
subclass of: RClass
disjoint with: R1
disjoint with: R2
disjoint with: RX
comment: definition: No residual tumor

R1
type: Class
subclass of: RClass
disjoint with: R2
disjoint with: RX
comment: definition: Microscopical residual tumor

R2
type: Class
subclass of: RClass
disjoint with: RX
comment: definition: Macroscopical residual tumor

RClass
type: Class
equivalent class: Class
  union of: R0
  union of: R1
  union of: R2
  union of: RX
subclass of: MammaryCarcinomaClass
comment: definition: residual tumor classification

RFSDays
type: Class
subclass of: Magnitude
subclass of: Restriction
  on property: hasIntegerValue
  some values from: integer
comment: Should be definable in terms of Relapse, end and start of ...
comment: RFSdays: Duration of relapse free survival

RTK
type: Class
subclass of: RhabdoidTumor
comment: Rhabdoid Tumor of the Kidney

RX
type: Class
subclass of: RClass
comment: definition: Residual tumor cannot be assessed

Radiotherapy
type: Class
subclass of: TherapeuticProcess
subclass of: Restriction
  on property: hasMagnitude
  on class: CumulativeDose
  qualified cardinality: 1
subclass of: Restriction
  on property: hasParticipant
  on class: PlasterFrame
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoneBy
  on class: Neoplasm
  min qualified cardinality: 1
subclass of: Restriction
  on property: hasParticipant
  on class: LinearParticleAccelerator
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasParticipant
  on class: Mask
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasPart
  some values from: IonizingRadiation
subclass of: Restriction
  on property: hasParticipant
  on class: VacuumCushion
  min qualified cardinality: 0

RadiotherapyPlanning
type: Class
subclass of: AdministrativeProcess
subclass of: Restriction
  on property: hasParticipant
  on class: MedicalImage
  min qualified cardinality: 0

RadiotherapyRiskOrgan
type: Class
subclass of: Role
subclass of: Restriction
  on property: implementedBy
  on class: OrganismalIndependentContinuant
  min qualified cardinality: 0

Reason
type: Class
subclass of: Role
subclass of: Restriction
  on property: implementedBy
  on class: ProcessualEntity
  min qualified cardinality: 0
subclass of: Restriction
  on property: describedBy
  on class: InformationObject
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasIdentifier
  on class: Name
  min qualified cardinality: 1

RecordingProcess
type: Class
subclass of: ClinicalDocumentation
subclass of: Restriction
  on property: undertakenBy
  min cardinality: 1
comment: i.e. the recording of data (medical data or whatnot)

RelapseFreeSurvival
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: hasMagnitude
  some values from: RFSDays
comment: This is not good as an organismal process anymore than Life is. This is more likely to be viewed as a role, however I don't think we can write simple restrictions for roles.

ResearchProcess
type: Class
subclass of: IntentionalProcess
comment: is similar to "investigation" in OBI

Resection
type: Class
subclass of: SurgicalOperation
comment: aka Excision

RhabdoidTumorPredispositionSyndrom
type: Class
subclass of: Syndrome
comment: Abb.: RTPS

SERM
type: Class
subclass of: ChemotherapyDrug
comment: Selective estrogen receptor modulators (SERMs) is a class of medication that acts on the estrogen receptor.

SalvageTherapy
type: Class
subclass of: Therapy
comment: Def.: Role of a TherapeuticProcess aiming to create a positive result after a previous TherapeuticProcess did not show effect.

Second
type: Class
subclass of: TemporalInterval
subclass of: Restriction
  on property: hasIntegerValue
  cardinality: 1
disjoint with: Week
disjoint with: Year

SecondaryMalignTumor
type: Class
subclass of: SecondaryTumor
subclass of: Restriction
  on property: implementedBy
  on class: MalignNeoplasm
  min qualified cardinality: 0

SecondaryTumor
type: Class
subclass of: Role
subclass of: Restriction
  on property: implementedBy
  on class: Neoplasm
  min qualified cardinality: 0

SensoryDisturbance
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0

SetOfCranialNerves
type: Class
subclass of: SetOfNeuralTreeOrgans
subclass of: Restriction
  on property: hasPart
  some values from: CranialNerve
subclass of: Restriction
  on property: implements
  on class: Malfunction
  min qualified cardinality: 0

Sight
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: hasQuality
  some values from: VisualAcuity
subclass of: Restriction
  on property: implements
  on class: Malfunction
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasQuality
  some values from: FieldOfVision
comment: The process of seeing.

Signing
type: Class
subclass of: AdministrativeProcess
subclass of: Restriction
  on property: hasQuality
  on class: Lateness
  min qualified cardinality: 0

SkinEdema
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: IntergumentarySystemSymptom
  min qualified cardinality: 0

SpinalAccessoryNerve
type: Class
subclass of: NeuralTreeOrgan
comment: Syn.: AccessoryNerve

StemCellHarvesting
type: Class
subclass of: TherapeuticProcess
subclass of: Restriction
  on property: hasMagnitude
  on class: NumberOfCycles
  qualified cardinality: 1
comment: Syn: Stem Cell Collection Syn: Stem Cell Apharesis

StemCellSample
type: Class
subclass of: SubstanceSample
subclass of: Restriction
  on property: hasMagnitude
  on class: NumberOfStemCells
  qualified cardinality: 1

SteroidHormoneReceptor
type: Class
subclass of: IntracellReceptor
comment: Steroid hormone receptors are intracellular receptors (typically cytoplasmic) that perform signal transduction for steroid hormones.

SubstanceSample
type: Class
subclass of: FiatObjectPart
subclass of: Restriction
  on property: sampledBy
  some values from: HumanBeing
subclass of: Restriction
  on property: storedIn
  on class: BioBankingOrganization
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoesMedicalProcess
  min cardinality: 0

SurgicalOperation
type: Class
subclass of: SurgicalProcedure
subclass of: Restriction
  on property: hasQuality
  on class: CompletenessLevel
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasQuality
  on class: FeasibilityLevel
  min qualified cardinality: 0
disjoint with: SurgicalSuture

Syndrome
type: Class
subclass of: NonInfectiousDisease
disjoint with: Tabagism
comment: or is it under qualities or processes?

T0
type: Class
subclass of: TClass
disjoint with: T2
disjoint with: T3
disjoint with: TX
comment: definition: No evidence of primary tumor

T1
type: Class
equivalent class: Class
  union of: T1a
  union of: T1b
  union of: T1c
  union of: T1mic
subclass of: TClass
comment: definition: Tumor 2 cm or less in greatest dimension

T1a
type: Class
subclass of: T1
disjoint with: T1b
disjoint with: T1c
disjoint with: T1mic
comment: definition: Tumor not more than 0.5 cm in greatest dimension

T1b
type: Class
subclass of: T1
disjoint with: T1c
disjoint with: T1mic
comment: definition: Tumor more than 0.5 cm but not more than 2 cm in greatest dimension

T1c
type: Class
subclass of: T1
disjoint with: T1mic
comment: definition: Tumor more than 1 cm but not more than 2 cm in greatest dimension

T1mic
type: Class
subclass of: T1
comment: definition: Microinvasion 0,1 cm or less in greatest dimension

T2
type: Class
subclass of: TClass
disjoint with: T3
disjoint with: TX
comment: definition: Tumor more than 2 cm but not more than 5 cm in greatest dimension

T3
type: Class
subclass of: TClass
disjoint with: TX
comment: definition: Tumor more than 5 cm in greatest dimension

T4
type: Class
equivalent class: Class
  union of: T4a
  union of: T4b
  union of: T4c
  union of: T4d
subclass of: TClass
comment: definition: Tumor of any size with direct extension to chest wall or skin

T4a
type: Class
subclass of: T4
disjoint with: T4b
disjoint with: T4c
disjoint with: T4d
comment: definition: Tumor with extension to chest wall

T4b
type: Class
subclass of: T4
disjoint with: T4c
disjoint with: T4d
comment: definition: Tumor with edema (including peau d’orange) or ulceration of the skin or satellite skin nodules confined to same breast

T4c
type: Class
subclass of: T4
disjoint with: T4d
comment: definition: Tumor with extension to chest wall and edema (including peau d’orange) or ulceration of the skin or satellite skin nodules confined to same breast

T4d
type: Class
subclass of: T4
comment: definition: Inflammatory carcinoma

TACChemo
type: Class
subclass of: Chemotherapy
disjoint with: VADChemo
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: TAC is named after the initials of the chemotherapy drugs involved, docetaxel (pronounced doe-se-tax-el), which is commonly known as Taxotere®, doxorubicin (docks-o-rou-bi-sin), which was originally called Adriamycin® and cyclophosphamide (sigh-clo-fos-fa-mide).

TClass
type: Class
equivalent class: Class
  union of: T0
  union of: T1
  union of: T2
  union of: T3
  union of: T4
  union of: TX
  union of: Tis
subclass of: ClinicalClassTNM
comment: definition: Primary tumor classification

TX
type: Class
subclass of: TClass
comment: definition: Primary tumor cannot be assessed

TechnicalObject
type: Class
subclass of: Object
comment: Def.: Any object developed and put together to serve a clearly outlined purpose.

TelephoneNumber
type: Class
subclass of: Identifier
subclass of: Restriction
  on property: hasStringValue
  cardinality: 1

Tetraparesis
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0
comment: aka "Quadriplegia"

TherapeuticProcess
type: Class
subclass of: MedicalProcess
subclass of: Restriction
  on property: precededBy
  some values from: Process
subclass of: Restriction
  on property: implements
  on class: Protocol
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoneBy
  some values from: Organism
subclass of: Restriction
  on property: implements
  on class: PreTherapy
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasPatient
  some values from: Organism
subclass of: Restriction
  on property: undertakenBy
  some values from: HumanBeing
subclass of: Restriction
  on property: hasQuality
  on class: TherapyAim
  qualified cardinality: 1
subclass of: Restriction
  on property: hasRole
  some values from: Therapy
subclass of: Restriction
  on property: hasQuality
  on class: CommonToxicityCriteriaGrade
  min qualified cardinality: 0
subclass of: Restriction
  on property: precedes
  some values from: Process
comment: aka treatment
comment: old name: TherapeuticProcedure
comment: Therapy in general.

Therapy
type: Class
subclass of: Role
subclass of: Restriction
  on property: roleOf
  all values from: Class
    union of: FiatProcessPart
    union of: Process
comment: Def.: Role of a SurgicalProcess aiming to remove a tumor after a previous biopsy.

TherapyDelay
type: Class
subclass of: AdministrativeProcess
subclass of: Restriction
  on property: hasReason
  on class: Reason
  min qualified cardinality: 0

TherapyPlan
type: Class
subclass of: Design
subclass of: Restriction
  on property: plans
  on class: ProcessualEntity
  min qualified cardinality: 1

TherapyTermination
type: Class
subclass of: AdministrativeProcess
comment: Def.: The process terminating a Therapeutic Process at an unforeseen time due to medical or adminstrative reasons.

Thrombosis
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: VascularSymptom
  min qualified cardinality: 0
subclass of: Restriction
  on property: isFunctionalOrStructural
  has value: Functional

Thyroid
type: Class
subclass of: LobularOrgan
subclass of: Restriction
  on property: undergoes
  on class: Lobectomy
  min qualified cardinality: 0

Tis
type: Class
equivalent class: Class
  union of: TisDCIS
  union of: TisLCIS
  union of: TisPaget
subclass of: TClass
comment: definition: Carcinoma in situ: Intraductal carcinoma, lobular carcinoma in situ, or Paget’s disease of the nipple with no tumor

TisDCIS
type: Class
subclass of: Tis
disjoint with: TisLCIS
disjoint with: TisPaget
comment: definition: Intraductal carcinoma

TisLCIS
type: Class
subclass of: Tis
disjoint with: TisPaget
comment: definition: lobular carcinoma in situ

TisPaget
type: Class
subclass of: Tis
comment: definition: Paget’s disease of the nipple with no tumor

TotalRBC
type: Class
subclass of: Density
comment: Total Red Blood Cells

Toxicity
type: Class
subclass of: Quality
subclass of: Restriction
  on property: implementedBy
  on class: Occurrent
  min qualified cardinality: 0
comment: aplies primarily to drugs/pharmaceutical substance, i.e. toxicity type of a drug

TransaminaseBiochemistry
type: Class
subclass of: HematologicalBiochemicalTest
subclass of: Restriction
  on property: reveals
  some values from: ALTCount
subclass of: Restriction
  on property: reveals
  some values from: ASTCount
subclass of: Restriction
  on property: reveals
  all values from: Class
    union of: ALTCount
    union of: ASTCount
comment: GOT/GPT

TransversalApproach
type: Class
subclass of: SurgicalApproach
comment: Transverser Zugang?

Trunk
type: Class
subclass of: SubdivisionOfBodyProper
subclass of: Restriction
  on property: undergoes
  on class: Ataxia
  min qualified cardinality: 0

TubulesFunctioning
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: implements
  on class: Malfunction
  min qualified cardinality: 0
comment: The processes that implement the normal functioning of the renal tubules (tubuli renales).

TumorCapsule
type: Class
subclass of: PathologicalFormation
subclass of: Restriction
  on property: partOf
  some values from: Neoplasm
subclass of: Restriction
  on property: hasQuality
  on class: Intactness
  min qualified cardinality: 0

TumorMarker
type: Class
subclass of: BiologicalMarker
subclass of: Restriction
  on property: roleOf
  on class: Catecholamine
  min qualified cardinality: 0

TumorResection
type: Class
subclass of: Resection
subclass of: Restriction
  on property: hasQuality
  on class: Radicality
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoneBy
  some values from: Neoplasm

TumorSample
type: Class
subclass of: HistologicalSample
subclass of: Restriction
  on property: outcomeOf
  all values from: Biopsy
subclass of: Restriction
  on property: hasQuality
  on class: Intactness
  min qualified cardinality: 0

TumorStage
type: Class
subclass of: TumorClass
subclass of: Restriction
  on property: hasIdentifier
  on class: Name
  min qualified cardinality: 0

Unconsiousness
type: Class
subclass of: StateOfAffairs
subclass of: Restriction
  on property: hasRole
  on class: NervousSystemSymptom
  min qualified cardinality: 0

UrineSample
type: Class
subclass of: SubstanceSample
subclass of: Restriction
  on property: implements
  on class: CatecholaminLevel
  min qualified cardinality: 0
subclass of: Restriction
  on property: sampledFrom
  some values from: Organism

VADChemo
type: Class
subclass of: Chemotherapy
disjoint with: VAPEC-BChemo
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: VAD is named after the initials of the chemotherapy drugs used, which are vincristine (pronounced vin-chris-teen), doxorubicin (docks-o-rou-bi-sin), which was originally known as Adriamycin® and dexamethasone (decks-a-meth-a-sone), which is a steroid.

VAPEC-BChemo
type: Class
subclass of: Chemotherapy
disjoint with: VinorelbineCarboplatinChemo
disjoint with: VinorelbineCisplatinChemo
comment: VAPEC-B is named after the initials of the chemotherapy drugs used, which are vincristine (pronounced vin-chris-teen), doxorubicin (docks-o-rou-bi-sin), which was originally known as Adriamycin®, prednisolone (pred-ni-so-lone), which is a steroid, etoposide (e-top-o-side), cyclophosphamide (sigh-clo-fos-fa-mide) and bleomycin (blee-o-my-sin).

VCDChemo
type: Class
subclass of: Chemotherapy
comment: A chemotherapy based on Vincristine, Cyclophosphamide and Doxorubin.

VDChemo
type: Class
subclass of: Chemotherapy
comment: A chemotherapy based on Vincristine and Doxorubicin.

VacuumCushion
type: Class
subclass of: TechnicalObject
subclass of: Restriction
  on property: participatesIn
  on class: Radiotherapy
  min qualified cardinality: 0

VariantAnatomicalStructure
type: Class
subclass of: AnatomicalStructure
comment: I think we should get rid of this here, please consult Anads Ontology. I am unsure....

VegetativeFunctioning
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: implements
  on class: Malfunction
  min qualified cardinality: 0

Vertebra
type: Class
subclass of: IrregularBone
subclass of: Restriction
  on property: placeOf
  on class: Paraplegia
  min qualified cardinality: 0

VertebralCanal
type: Class
subclass of: AnatomicalCompartment
comment: Syn.: Spinal Canal

VinorelbineCarboplatinChemo
type: Class
subclass of: Chemotherapy
disjoint with: VinorelbineCisplatinChemo
comment: The treatment involves the two chemotherapy drugs vinorelbine (pronounced vin-or-ell-been), which is also known as Navelbine®, and carboplatin (car-bo-pla-tin).

VinorelbineCisplatinChemo
type: Class
subclass of: Chemotherapy
comment: The chemotherapy drugs used are: vinorelbine (pronounced vi-nor-el-been), which is also known as Navelbine®, and cisplatin (sis-pla-tin), which is a platinum-based drug.

Vomiting
type: Class
subclass of: OrganismalProcess
subclass of: Restriction
  on property: hasRole
  on class: AlimentarySystemSymptom
  min qualified cardinality: 0

WBC
type: Class
subclass of: HematologicalBiochemicalTest
subclass of: Restriction
  on property: reveals
  some values from: WBCCount
subclass of: Restriction
  on property: reveals
  all values from: WBCCount
comment: CountingWhiteBloodCells

WBCCount
type: Class
subclass of: Density
comment: The number of leukocytes in the blood

Week
type: Class
subclass of: TemporalInterval
subclass of: Restriction
  on property: hasIntegerValue
  cardinality: 1
disjoint with: Year

WindowTherapy
type: Class
subclass of: Therapy
comment: Def: Role of a Therapy that is a) not tested and b) is done before the regular (well-established) Therapy.

Year
type: Class
subclass of: TemporalInterval
subclass of: Restriction
  on property: hasIntegerValue
  cardinality: 1

pCRRate
type: Class
subclass of: Magnitude
comment: Pathological complete response is defined as the complete absence of intact tumour cells in the resected specimen. Not sure what difference may be between pCRRate and pCRStatus; for now, I've kept them both.

pCRStatus
type: Class
equivalent class: Class
  intersection of: pN0
  intersection of: Class
    union of: pT0
    union of: pTis
subclass of: Quality
subclass of: Restriction
  on property: hasBooleanValue
  cardinality: 1

pM0
type: Class
subclass of: pMClass
disjoint with: pM1
disjoint with: pMX
comment: definition: No distant metastasis

pM1
type: Class
subclass of: pMClass
disjoint with: pMX
comment: definition: Distant metastasis (includes metastasis to ipsilateral supraventricular lymph node[s])

pMX
type: Class
subclass of: pMClass
comment: definition: Presence of distant metastasis cannot be assessed

pN0
type: Class
subclass of: pNClass
disjoint with: pN1mi
disjoint with: pNX
comment: definition: No regional lymph node metastasis

pN1
type: Class
equivalent class: Class
  union of: pN1a
  union of: pN1b
  union of: pN1c
subclass of: pNClass
comment: definition: Metastasis to movable ipsilateral axillary lymph node(s)

pN1a
type: Class
subclass of: pN1
disjoint with: pN1b
disjoint with: pN1c
comment: definition: Only micrometastasis (none larger than 0.2 cm)

pN1b
type: Class
subclass of: pN1
disjoint with: pN1c
comment: definition: Metastasis to lymph nodes, any larger than 0.2 cm

pN1c
type: Class
subclass of: pN1
comment: definition: Metastasis to a lymph node 2 cm or more in greatest dimension

pN1mi
type: Class
subclass of: pNClass
disjoint with: pNX
comment: definition: Micrometastasis greater than 0,2 mm but not more than 0,2 cm

pN2
type: Class
equivalent class: Class
  union of: pN2a
  union of: pN2b
subclass of: pNClass
comment: definition: Metastasis to ipsilateral axillary lymph nodes that are fixed to one another or to other structures

pN2a
type: Class
subclass of: pN2
disjoint with: pN2b
comment: definition: Metastases in 4 to 9 axillary lymph nodes, at least one metastasis greater than 0,2 cm in greatest dimension

pN2b
type: Class
subclass of: pN2
comment: definition: Metastases to clinically identifiable lymph node(s) along the Arteria mammaria without axillary lymph node metastases

pN3
type: Class
equivalent class: Class
  union of: pN3a
  union of: pN3b
  union of: pN3c
subclass of: pNClass
comment: definition: Metastasis to ipsilateral internal mammary lymph node(s)

pN3a
type: Class
subclass of: pN3
disjoint with: pN3b
disjoint with: pN3c
comment: definition: Metastasis or Metastases in 10 or more ipsilateral axillary lymoh nodes, at least one greater than 0,2 cm or in ipsilateral infraclaviculary lymph nodes.

pN3b
type: Class
subclass of: pN3
disjoint with: pN3c
comment: definition: Metastasis or Metastases in clinically identifiable lymph nodes along the Arteria mammaria interna with at least one axillary lymph node metastasis or lymph node metastases in more than 3 axillary lymph nodes and in lymph nodes along the Arteria mammaria interna, proved by analysis of the sentinel lymph node(s) but not clinically identifiable

pN3c
type: Class
subclass of: pN3
comment: definition: Metastasis or Metastases in ipsilateral supraclaviculary lymph nodes

pNX
type: Class
subclass of: pNClass
comment: definition: Regional lymph nodes cannot be assessed (eg, previously removed, or not removed for pathologic study)

pT0
type: Class
subclass of: pTClass
disjoint with: pT2
disjoint with: pT3
disjoint with: pTX
comment: definition: No evidence of primary tumor

pT1
type: Class
equivalent class: Class
  union of: pT1a
  union of: pT1b
  union of: pT1c
  union of: pT1mic
subclass of: pTClass
comment: definition: Tumor 2 cm or less in greatest dimension

pT1a
type: Class
subclass of: pT1
disjoint with: pT1b
disjoint with: pT1c
disjoint with: pT1mic
comment: definition: Tumor not more than 0.5 cm in greatest dimension

pT1b
type: Class
subclass of: pT1
disjoint with: pT1c
disjoint with: pT1mic
comment: definition: Tumor more than 0.5 cm but not more than 2 cm in greatest dimension

pT1c
type: Class
subclass of: pT1
disjoint with: pT1mic
comment: definition: Tumor more than 1 cm but not more than 2 cm in greatest dimension

pT1mic
type: Class
subclass of: pT1
comment: definition: Microinvasion 0,1 cm or less in greatest dimension

pT2
type: Class
subclass of: pTClass
disjoint with: pT3
disjoint with: pTX
comment: definition: Tumor more than 2 cm but not more than 5 cm in greatest dimension

pT3
type: Class
subclass of: pTClass
disjoint with: pTX
comment: definition: Tumor more than 5 cm in greatest dimension

pT4
type: Class
equivalent class: Class
  union of: pT4a
  union of: pT4b
  union of: pT4c
  union of: pT4d
subclass of: pTClass
comment: definition: Tumor of any size with direct extension to chest wall or skin

pT4a
type: Class
subclass of: pT4
disjoint with: pT4b
disjoint with: pT4c
disjoint with: pT4d
comment: definition: Tumor with extension to chest wall

pT4b
type: Class
subclass of: pT4
disjoint with: pT4c
disjoint with: pT4d
comment: definition: Tumor with edema (including peau d’orange) or ulceration of the skin or satellite skin nodules confined to same breast

pT4c
type: Class
subclass of: pT4
disjoint with: pT4d
comment: definition: Tumor with extension to chest wall and edema (including peau d’orange) or ulceration of the skin or satellite skin nodules confined to same breast

pT4d
type: Class
subclass of: pT4
comment: definition: Inflammatory carcinoma

pTX
type: Class
subclass of: pTClass
comment: definition: Primary tumor cannot be assessed

pTis
type: Class
equivalent class: Class
  union of: pTisDCIS
  union of: pTisLCIS
  union of: pTisPaget
subclass of: pTClass
comment: definition: Carcinoma in situ: Intraductal carcinoma, lobular carcinoma in situ, or Paget’s disease of the nipple with no tumor

pTisDCIS
type: Class
subclass of: pTis
disjoint with: pTisLCIS
disjoint with: pTisPaget
comment: definition: Intraductal carcinoma

pTisLCIS
type: Class
subclass of: pTis
disjoint with: pTisPaget
comment: definition: lobular carcinoma in situ

pTisPaget
type: Class
subclass of: pTis
comment: definition: Paget’s disease of the nipple with no tumor

IndependentContinuant
type: Class
subclass of: Restriction
  on property: undergoes
  on class: Process
  min qualified cardinality: 0
subclass of: Restriction
  on property: undergoes
  on class: ProcessAggregate
  min qualified cardinality: 0

Object
type: Class
subclass of: Restriction
  on property: issues
  on class: InformationObject
  min qualified cardinality: 0

SpatialRegion
type: Class
subclass of: Restriction
  on property: hasIdentifier
  on class: Address
  min qualified cardinality: 0

FiatProcessPart
type: Class
subclass of: Restriction
  on property: partOf
  some values from: Process
subclass of: Restriction
  on property: compatibleWith
  some values from: ProcessualEntity
subclass of: Restriction
  on property: revealsNumberOfLungMetastases
  min cardinality: 0
subclass of: Restriction
  on property: hasBeginning
  on class: Class
    union of: FiatProcessPart
    union of: Process
    union of: ProcessAggregate
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasOutcome
  on class: ProcessualEntity
  min qualified cardinality: 0

Occurrent
type: Class
subclass of: Restriction
  on property: hasQuality
  on class: Toxicity
  min qualified cardinality: 0

Process
type: Class
subclass of: Restriction
  on property: compatibleWith
  some values from: ProcessualEntity
subclass of: Restriction
  on property: hasQuality
  on class: ProcessOrigin
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasBeginning
  on class: Class
    union of: FiatProcessPart
    union of: Process
    union of: ProcessAggregate
  min qualified cardinality: 0
subclass of: Restriction
  on property: precededBy
  some values from: Process
subclass of: Restriction
  on property: hasOutcome
  on class: ProcessualEntity
  min qualified cardinality: 0
subclass of: Restriction
  on property: implements
  on class: Complication
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasRole
  on class: Reason
  min qualified cardinality: 0
subclass of: Restriction
  on property: precedes
  some values from: Process
subclass of: Restriction
  on property: hasDate
  some values from: date
subclass of: Restriction
  on property: revealsNumberOfLungMetastases
  min cardinality: 0
subclass of: Restriction
  on property: hasProcessStart
  cardinality: 1
subclass of: Restriction
  on property: hasPart
  some values from: FiatProcessPart
subclass of: Restriction
  on property: hasProcessEnd
  cardinality: 1

ProcessAggregate
type: Class
subclass of: Restriction
  on property: compatibleWith
  some values from: ProcessualEntity
subclass of: Restriction
  on property: hasBeginning
  on class: Class
    union of: FiatProcessPart
    union of: Process
    union of: ProcessAggregate
  min qualified cardinality: 0
subclass of: Restriction
  on property: hasPart
  some values from: Process
subclass of: Restriction
  on property: hasOutcome
  on class: ProcessualEntity
  min qualified cardinality: 0
subclass of: Restriction
  on property: revealsNumberOfLungMetastases
  min cardinality: 0

ProcessBoundary
type: Class
subclass of: Restriction
  on property: locatedIn
  some values from: SpatialRegion
subclass of: Restriction
  on property: hasDateTime
  cardinality: 1
subclass of: Restriction
  on property: situatedIn
  some values from: Site
subclass of: Restriction
  on property: hasDate
  some values from: date

EU-RHAB
type: ClinicalStudy
type: Thing
comment: European Rhabdoid Study

StageI
type: Thing
comment: definition: Tumor confined to kidney and completely resected

StageII
type: Thing
comment: definition: Microscopic residual tumor, tumor penetration through renal capsule

StageIII
type: Thing
comment: definition: Gross residual disease confined to abdomen, lymph node involvement, diffuse peritoneal contamination (tumor rupture)

StageIV
type: Thing
comment: definition: Hematogenous Metastases: lung, noncontiguous liver, bone, and brain

StageV
type: Thing
comment: definition: Bilateral renal involvement at diagnosis

Restriction
on property: undergoes
on class: MaddenMastectomy
min qualified cardinality: 0

Restriction
on property: receives
on class: InformationObject
min qualified cardinality: 0

Restriction
on property: hasIdentifier
on class: FirstName
min qualified cardinality: 0

Restriction
on property: undergoes
on class: MUGAScan
min qualified cardinality: 0

Restriction
on property: undergoes
on class: ProtocolChange
min qualified cardinality: 0

Restriction
on property: undergoes
on class: MagneticResonanceImaging
min qualified cardinality: 0

Restriction
on property: hasDisease
min cardinality: 0

Restriction
on property: hasGender
cardinality: 1

Restriction
on property: hasMagnitude
on class: KarnofskyRating
min qualified cardinality: 0

Restriction
on property: hasHeight
cardinality: 1

Restriction
on property: undergoes
on class: Computertomography
min qualified cardinality: 0

Restriction
on property: uses
on class: HearingDevice
min qualified cardinality: 0

Restriction
on property: undergoes
on class: BreastResection
min qualified cardinality: 0

Restriction
on property: undergoesMedicalProcess
min cardinality: 0

Restriction
on property: hasWeight
cardinality: 1

Restriction
on property: undergoes
on class: SkinSparingTotalMastectomy
min qualified cardinality: 0

Restriction
on property: hasSibling
min cardinality: 0

Restriction
on property: undergoes
on class: LostToFollowUp
min qualified cardinality: 0

Restriction
on property: undergoes
on class: ECG
min qualified cardinality: 0

Restriction
on property: undergoes
on class: ProcessualEntity
min qualified cardinality: 0

Restriction
on property: hasIdentifier
on class: LastName
min qualified cardinality: 0

Restriction
on property: hasMother
cardinality: 1

Restriction
on property: undergoes
on class: Mastectomy
min qualified cardinality: 0